Literature DB >> 16893347

Blood-brain barrier and chemotherapeutic treatment of brain tumors.

Nienke A de Vries1, Jos H Beijnen, Willem Boogerd, Olaf van Tellingen.   

Abstract

The blood-brain barrier (BBB) is of pivotal importance to maintain homeostasis of the CNS, as it closely regulates the composition of the interstitial fluid in the brain. Unfortunately, malignancies that grow within the CNS may evade chemotherapeutic drugs using the same barrier, making this disease refractory to most chemotherapy regimens. This review will outline the impact of the BBB in brain cancer and discuss the efforts that have been made to enhance the drug exposure of brain tumors. Although this review will focus on the role of the BBB in primary brain cancer (malignant glioma), its impact on brain metastases will also be briefly discussed.

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Year:  2006        PMID： 16893347     DOI： 10.1586/14737175.6.8.1199

Source DB:  PubMed          Journal:  Expert Rev Neurother        ISSN： 1473-7175            Impact factor:   4.618


  45 in total

1.  RhoA-mediated potential regulation of blood-tumor barrier permeability by bradykinin.

Authors:  Teng Ma; Yixue Xue
Journal:  J Mol Neurosci       Date:  2010-04-06       Impact factor: 3.444

2.  Kinetic analysis of novel mono- and multivalent VHH-fragments and their application for molecular imaging of brain tumours.

Authors:  U Iqbal; U Trojahn; H Albaghdadi; J Zhang; M O'Connor-McCourt; D Stanimirovic; B Tomanek; G Sutherland; A Abulrob
Journal:  Br J Pharmacol       Date:  2010-06       Impact factor: 8.739

3.  Imaging of brain tumors with paramagnetic vesicles targeted to phosphatidylserine.

Authors:  Patrick M Winter; John Pearce; Zhengtao Chu; Christopher M McPherson; Ray Takigiku; Jing-Huei Lee; Xiaoyang Qi
Journal:  J Magn Reson Imaging       Date:  2014-05-06       Impact factor: 4.813

4.  Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study.

Authors:  Roh-Eul Yoo; Seung Hong Choi; Tae Min Kim; Chul-Kee Park; Sung-Hye Park; Jae-Kyung Won; Il Han Kim; Soon Tae Lee; Hye Jeong Choi; Sung-Hye You; Koung Mi Kang; Tae Jin Yun; Ji-Hoon Kim; Chul-Ho Sohn
Journal:  Eur Radiol       Date:  2016-12-14       Impact factor: 5.315

5.  Opposing effects of pigment epithelium-derived factor on breast cancer cell versus neuronal survival: implication for brain metastasis and metastasis-induced brain damage.

Authors:  Daniel P Fitzgerald; Preeti Subramanian; Monika Deshpande; Christian Graves; Ira Gordon; Yongzhen Qian; Yeva Snitkovsky; David J Liewehr; Seth M Steinberg; José D Paltán-Ortiz; Mary M Herman; Kevin Camphausen; Diane Palmieri; S Patricia Becerra; Patricia S Steeg
Journal:  Cancer Res       Date:  2012-01-01       Impact factor: 12.701

6.  Dissecting and rebuilding the glioblastoma microenvironment with engineered materials.

Authors:  Kayla J Wolf; Joseph Chen; Jason Coombes; Manish K Aghi; Sanjay Kumar
Journal:  Nat Rev Mater       Date:  2019-08-16       Impact factor: 66.308

7.  Neoadjuvant targeting of glioblastoma multiforme with radiolabeled DOTAGA-substance P--results from a phase I study.

Authors:  Dominik Cordier; Flavio Forrer; Stefan Kneifel; Martin Sailer; Luigi Mariani; Helmut Mäcke; Jan Müller-Brand; Adrian Merlo
Journal:  J Neurooncol       Date:  2010-03-10       Impact factor: 4.130

8.  P-glycoprotein and breast cancer resistance protein restrict the brain penetration of the CDK4/6 inhibitor palbociclib.

Authors:  Mark C de Gooijer; Ping Zhang; Nishita Thota; Isabel Mayayo-Peralta; Levi C M Buil; Jos H Beijnen; Olaf van Tellingen
Journal:  Invest New Drugs       Date:  2015-07-01       Impact factor: 3.850

Review 9.  Crossing the barrier: treatment of brain tumors using nanochain particles.

Authors:  Efstathios Karathanasis; Ketan B Ghaghada
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2016-01-09

Review 10.  Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux.

Authors:  Fan Lin; Mark C de Gooijer; Diana Hanekamp; Dieta Brandsma; Jos H Beijnen; Olaf van Tellingen
Journal:  CNS Oncol       Date:  2013-05
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