Literature DB >> 19731897

Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles.

Romain Noël1, Xinyi Song, Rong Jiang, Michael J Chalmers, Patrick R Griffin, Theodore M Kamenecka.   

Abstract

A general and efficient method for the preparation of 3-amino-1,2,4-triazoles has been developed. The desired 3-amino-1,2,4-triazoles (1) were prepared in good overall yield via two convergent routes. The key intermediate within both routes is substituted hydrazinecarboximidamide derivative 2.

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Year:  2009        PMID： 19731897      PMCID： PMC2890234          DOI： 10.1021/jo9016502

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  6 in total

1.  Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles.

Authors:  Gergely M Makara; Yao Ma; Laura Margarida
Journal:  Org Lett       Date:  2002-05-16       Impact factor: 6.005

2.  Cloning and molecular analysis of the Aspergillus terreus arg1 gene coding for an ornithine carbamoyltransferase.

Authors:  L Ventura; J A Pérez-González; D Ramón
Journal:  FEMS Microbiol Lett       Date:  1997-04-15       Impact factor: 2.742

3.  Synthesis and pharmacological activity of triazole derivatives inhibiting eosinophilia.

Authors:  Y Naito; F Akahoshi; S Takeda; T Okada; M Kajii; H Nishimura; M Sugiura; C Fukaya; Y Kagitani
Journal:  J Med Chem       Date:  1996-07-19       Impact factor: 7.446

4.  Inhibition of antioxidants and hyperthermia enhance bleomycin-induced cytotoxicity and lipid peroxidation in Chinese hamster ovary cells.

Authors:  A Khadir; J Verreault; D A Averill
Journal:  Arch Biochem Biophys       Date:  1999-10-15       Impact factor: 4.013

5.  Rational design, synthesis, and structure-activity relationships of aryltriazoles as novel corticotropin-releasing factor-1 receptor antagonists.

Authors:  Richard F Lowe; Jodene Nelson; Trunghau N Dang; Paul D Crowe; Anil Pahuja; James R McCarthy; Dimitri E Grigoriadis; Paul Conlon; John Saunders; Chen Chen; Thomas Szabo; Ta Kung Chen; Haig Bozigian
Journal:  J Med Chem       Date:  2005-03-10       Impact factor: 7.446

6.  Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore.

Authors:  Joseph P Marino; Paul W Fisher; Glenn A Hofmann; Robert B Kirkpatrick; Cheryl A Janson; Randall K Johnson; Chun Ma; Michael Mattern; Thomas D Meek; M Dominic Ryan; Christina Schulz; Ward W Smith; David G Tew; Thaddeus A Tomazek; Daniel F Veber; Wenfang C Xiong; Yuuichi Yamamoto; Keizo Yamashita; Guang Yang; Scott K Thompson
Journal:  J Med Chem       Date:  2007-07-18       Impact factor: 7.446
  6 in total
  1 in total

1.  One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles.

Authors:  Dmytro S Radchenko; Vasyl S Naumchyk; Igor Dziuba; Andrii A Kyrylchuk; Kateryna E Gubina; Yurii S Moroz; Oleksandr O Grygorenko
Journal:  Mol Divers       Date:  2021-04-02       Impact factor: 3.364
  1 in total

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