Literature DB >> 12000290

Solid-phase synthesis of 3-alkylamino-1,2,4-triazoles.

Gergely M Makara1, Yao Ma, Laura Margarida.   

Abstract

[reaction: see text] A solid-phase synthesis of trisubstituted 3-alkylamino-1,2,4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds with regioselectivity and high purity.

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Year:  2002        PMID： 12000290     DOI： 10.1021/ol025821i

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles.

Authors:  Romain Noël; Xinyi Song; Rong Jiang; Michael J Chalmers; Patrick R Griffin; Theodore M Kamenecka
Journal:  J Org Chem       Date:  2009-10-02       Impact factor: 4.354

2.  Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties.

Authors:  Sabrina Neves Santos; Gabriela Alves de Souza; Thiago Moreira Pereira; Daiana Portella Franco; Catarina de Nigris Del Cistia; Carlos Mauricio R Sant'Anna; Renata Barbosa Lacerda; Arthur Eugen Kümmerle
Journal:  RSC Adv       Date:  2019-07-01       Impact factor: 4.036
  2 in total

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