Ali Samii1, Mahyar Etminan, Matthew O Wiens, Siavash Jafari. 1. Department of Neurology, University of Washington, and the Seattle VA Parkinson Disease Research Education and Clinical Center, Seattle, Washington, USA. asamii@u.washington.edu
Abstract
BACKGROUND: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). OBJECTIVE: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. METHODS: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). RESULTS: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). CONCLUSIONS: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.
BACKGROUND: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). OBJECTIVE: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. METHODS: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). RESULTS: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). CONCLUSIONS: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.
Authors: B Ravina; D Eidelberg; J E Ahlskog; R L Albin; D J Brooks; M Carbon; V Dhawan; A Feigin; S Fahn; M Guttman; K Gwinn-Hardy; H McFarland; R Innis; R G Katz; K Kieburtz; S J Kish; N Lange; J W Langston; K Marek; L Morin; C Moy; D Murphy; W H Oertel; G Oliver; Y Palesch; W Powers; J Seibyl; K D Sethi; C W Shults; P Sheehy; A J Stoessl; R Holloway Journal: Neurology Date: 2005-01-25 Impact factor: 9.910
Authors: Karen M Powers; Denise M Kay; Stewart A Factor; Cyrus P Zabetian; Donald S Higgins; Ali Samii; John G Nutt; Alida Griffith; Berta Leis; John W Roberts; Erica D Martinez; Jennifer S Montimurro; Harvey Checkoway; Haydeh Payami Journal: Mov Disord Date: 2008-01 Impact factor: 10.338
Authors: Marjolijn Bornebroek; Lonneke M L de Lau; Mendel D M Haag; Peter J Koudstaal; Albert Hofman; Bruno H C Stricker; Monique M B Breteler Journal: Neuroepidemiology Date: 2007-09-11 Impact factor: 3.282