Thermoregulation and the role of calcium signalling in neurotransmission.

Understanding the functional capacity of the human brain at a molecular level continues to be a challenge despite modern scientific and technological advances. Extreme variations in thermoregulation, whether induced by genetic predisposition or changes in internal, external or central factors, appear to be caused by altered calcium signalling at the neurotransmitter level and are likely due to a compromised blood brain barrier (BBB) in the hypothalamic region. The objective of this hypothesis is to explore the complicated interactions between neurotransmission, calcium signalling, and thermoregulation resulting from a challenged BBB in the hypothalamic region of the brain.