Literature DB >> 16691292

Neuronal calcium sensor-1 enhancement of InsP3 receptor activity is inhibited by therapeutic levels of lithium.

Christina Schlecker1, Wolfgang Boehmerle, Andreas Jeromin, Brenda DeGray, Anurag Varshney, Yogendra Sharma, Klara Szigeti-Buck, Barbara E Ehrlich.   

Abstract

Regulation and dysregulation of intracellular calcium (Ca2+) signaling via the inositol 1,4,5-trisphosphate receptor (InsP3R) has been linked to many cellular processes and pathological conditions. In the present study, addition of neuronal calcium sensor-1 (NCS-1), a high-affinity, low-capacity, calcium-binding protein, to purified InsP3R type 1 (InsP3R1) increased the channel activity in both a calcium-dependent and -independent manner. In intact cells, enhanced expression of NCS-1 resulted in increased intracellular calcium release upon stimulation of the phosphoinositide signaling pathway. To determine whether InsP3R1/NCS-1 interaction could be functionally relevant in bipolar disorders, conditions in which NCS-1 is highly expressed, we tested the effect of lithium, a salt widely used for treatment of bipolar disorders. Lithium inhibited the enhancing effect of NCS-1 on InsP3R1 function, suggesting that InsP3R1/NCS-1 interaction is an essential component of the pathomechanism of bipolar disorder.

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Year:  2006        PMID： 16691292      PMCID： PMC1459068          DOI： 10.1172/JCI22466

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  40 in total

1.  Local and global spontaneous calcium events regulate neurite outgrowth and onset of GABAergic phenotype during neural precursor differentiation.

Authors:  Francesca Ciccolini; Tony J Collins; Juliana Sudhoelter; Peter Lipp; Michael J Berridge; Martin D Bootman
Journal:  J Neurosci       Date:  2003-01-01       Impact factor: 6.167

Review 2.  Calcium signalling: dynamics, homeostasis and remodelling.

Authors:  Michael J Berridge; Martin D Bootman; H Llewelyn Roderick
Journal:  Nat Rev Mol Cell Biol       Date:  2003-07       Impact factor: 94.444

3.  Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells.

Authors:  Manisha Rajebhosale; Sam Greenwood; Jolanta Vidugiriene; Andreas Jeromin; Sabine Hilfiker
Journal:  J Biol Chem       Date:  2002-12-05       Impact factor: 5.157

4.  Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells.

Authors:  Schuichi Koizumi; Patrizia Rosa; Gary B Willars; R A John Challiss; Elena Taverna; Maura Francolini; Martin D Bootman; Peter Lipp; Kazuhide Inoue; John Roder; Andreas Jeromin
Journal:  J Biol Chem       Date:  2002-05-28       Impact factor: 5.157

5.  Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels.

Authors:  Jun Yang; Sean McBride; Don-On Daniel Mak; Noga Vardi; Krzysztof Palczewski; Françoise Haeseleer; J Kevin Foskett
Journal:  Proc Natl Acad Sci U S A       Date:  2002-05-28       Impact factor: 11.205

6.  Immunocytochemical localization of neuronal calcium sensor-1 in the hippocampus and cerebellum of the mouse, with special reference to presynaptic terminals.

Authors:  S Jinno; A Jeromin; J Roder; T Kosaka
Journal:  Neuroscience       Date:  2002       Impact factor: 3.590

7.  IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis.

Authors:  Nadia Bahi; Gaelle Friocourt; Alain Carrié; Margaret E Graham; Jamie L Weiss; Philippe Chafey; Fabien Fauchereau; Robert D Burgoyne; Jamel Chelly
Journal:  Hum Mol Genet       Date:  2003-06-15       Impact factor: 6.150

8.  Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients.

Authors:  Phil Ok Koh; Ashiwel S Undie; Nadine Kabbani; Robert Levenson; Patricia S Goldman-Rakic; Michael S Lidow
Journal:  Proc Natl Acad Sci U S A       Date:  2002-12-20       Impact factor: 11.205

9.  Interaction with neuronal calcium sensor NCS-1 mediates desensitization of the D2 dopamine receptor.

Authors:  Nadine Kabbani; Laszlo Negyessy; Ridwan Lin; Patricia Goldman-Rakic; Robert Levenson
Journal:  J Neurosci       Date:  2002-10-01       Impact factor: 6.167

10.  Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.

Authors:  M Matsumoto; T Nakagawa; T Inoue; E Nagata; K Tanaka; H Takano; O Minowa; J Kuno; S Sakakibara; M Yamada; H Yoneshima; A Miyawaki; Y Fukuuchi; T Furuichi; H Okano; K Mikoshiba; T Noda
Journal:  Nature       Date:  1996-01-11       Impact factor: 49.962
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  61 in total

1.  Blood brain barrier: the role of pyridoxine.

Authors:  Atmaram Yarlagadda; Anita H Clayton
Journal:  Psychiatry (Edgmont)       Date:  2007-08

2.  Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism.

Authors:  Wolfgang Boehmerle; Ute Splittgerber; Michael B Lazarus; Kathleen M McKenzie; David G Johnston; David J Austin; Barbara E Ehrlich
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-17       Impact factor: 11.205

Review 3.  Dysregulation of neural calcium signaling in Alzheimer disease, bipolar disorder and schizophrenia.

Authors:  Michael J Berridge
Journal:  Prion       Date:  2012-08-16       Impact factor: 3.931

4.  Thermoregulation and the role of calcium signalling in neurotransmission.

Authors:  Atmaram Yarlagadda; Anita H Clayton
Journal:  Psychiatry (Edgmont)       Date:  2008-12

5.  CaBP1, a neuronal Ca2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions.

Authors:  Congmin Li; Masahiro Enomoto; Ana M Rossi; Min-Duk Seo; Taufiq Rahman; Peter B Stathopulos; Colin W Taylor; Mitsuhiko Ikura; James B Ames
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-06       Impact factor: 11.205

Review 6.  Signaling in muscle contraction.

Authors:  Ivana Y Kuo; Barbara E Ehrlich
Journal:  Cold Spring Harb Perspect Biol       Date:  2015-02-02       Impact factor: 10.005

Review 7.  Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.

Authors:  Polina Egorova; Elena Popugaeva; Ilya Bezprozvanny
Journal:  Semin Cell Dev Biol       Date:  2015-04-04       Impact factor: 7.727

Review 8.  Calcium Sensors in Neuronal Function and Dysfunction.

Authors:  Robert D Burgoyne; Nordine Helassa; Hannah V McCue; Lee P Haynes
Journal:  Cold Spring Harb Perspect Biol       Date:  2019-05-01       Impact factor: 10.005

9.  Calpain inhibitor and ibudilast rescue β cell functions in a cellular model of Wolfram syndrome.

Authors:  Lien D Nguyen; Tom T Fischer; Damien Abreu; Alfredo Arroyo; Fumihiko Urano; Barbara E Ehrlich
Journal:  Proc Natl Acad Sci U S A       Date:  2020-07-06       Impact factor: 11.205

Review 10.  Current Understanding of the Role of Neuronal Calcium Sensor 1 in Neurological Disorders.

Authors:  Julia Bandura; Zhong-Ping Feng
Journal:  Mol Neurobiol       Date:  2019-02-04       Impact factor: 5.590
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