PURPOSE: Previously, we have shown that p27 may be a potential predictive biomarker for the selection of premenopausal women with early-stage hormone-responsive breast cancer for adjuvant endocrine therapy. The purpose of the present study was to assess the clinical relevance of p27 expression in postmenopausal hormone receptor-positive breast cancer patients who were treated with adjuvant tamoxifen therapy. EXPERIMENTAL DESIGN: We determined the expression of p27 by immunohistochemistry in the surgical specimens of breast carcinoma patients who had been enrolled in Austrian Breast and Colorectal Cancer Study Group Trial 06 and received tamoxifen for 5 years. Early relapse and death within the first 5 years of follow-up were analyzed using Cox models adjusted for clinical and pathologic factors. RESULTS: p27 expression was high (>70% p27-positive tumor cells) in 252 of 483 (52%) tumor specimens and was associated with favorable outcome of the patients. Women with high p27 expression had a significantly longer disease-free survival (adjusted hazard ratio for relapse, 0.22; 95% confidence interval, 0.11-0.42; P < 0.001) and overall survival (adjusted hazard ratio for death, 0.39; 95% confidence interval, 0.21-0.72; P = 0.002) as compared with women with low p27 expression. CONCLUSION: Low p27 expression independently predicts early relapse and death in postmenopausal women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen for 5 years.
PURPOSE: Previously, we have shown that p27 may be a potential predictive biomarker for the selection of premenopausal women with early-stage hormone-responsive breast cancer for adjuvant endocrine therapy. The purpose of the present study was to assess the clinical relevance of p27 expression in postmenopausal hormone receptor-positive breast cancerpatients who were treated with adjuvant tamoxifen therapy. EXPERIMENTAL DESIGN: We determined the expression of p27 by immunohistochemistry in the surgical specimens of breast carcinomapatients who had been enrolled in Austrian Breast and Colorectal Cancer Study Group Trial 06 and received tamoxifen for 5 years. Early relapse and death within the first 5 years of follow-up were analyzed using Cox models adjusted for clinical and pathologic factors. RESULTS:p27 expression was high (>70% p27-positive tumor cells) in 252 of 483 (52%) tumor specimens and was associated with favorable outcome of the patients. Women with high p27 expression had a significantly longer disease-free survival (adjusted hazard ratio for relapse, 0.22; 95% confidence interval, 0.11-0.42; P < 0.001) and overall survival (adjusted hazard ratio for death, 0.39; 95% confidence interval, 0.21-0.72; P = 0.002) as compared with women with low p27 expression. CONCLUSION: Low p27 expression independently predicts early relapse and death in postmenopausal women with early-stage, hormone receptor-positive breast cancer who received adjuvant tamoxifen for 5 years.
Authors: Amy R Peck; Agnieszka K Witkiewicz; Chengbao Liu; Ginger A Stringer; Alexander C Klimowicz; Edward Pequignot; Boris Freydin; Thai H Tran; Ning Yang; Anne L Rosenberg; Jeffrey A Hooke; Albert J Kovatich; Marja T Nevalainen; Craig D Shriver; Terry Hyslop; Guido Sauter; David L Rimm; Anthony M Magliocco; Hallgeir Rui Journal: J Clin Oncol Date: 2011-05-16 Impact factor: 44.544
Authors: Deepu Mirchandani; Daniel F Roses; Giorgio Inghirami; Anne Zeleniuch-Jacquotte; Joan Cangiarella; Amber Guth; Rachael Ann Safyan; Silvia C Formenti; Michele Pagano; Franco Muggia Journal: Anticancer Res Date: 2011-12 Impact factor: 2.480
Authors: Katie R Hagen; Xiangbin Zeng; Mi-Young Lee; Shannon Tucker Kahn; Mary Kathryn Harrison Pitner; Sandra S Zaky; Yuan Liu; Ruth M O'Regan; Xingming Deng; Harold I Saavedra Journal: Cell Div Date: 2013-07-25 Impact factor: 5.130