Literature DB >> 19723507

Biochemical characterisation of the SWI/SNF family member HLTF.

Craig MacKay1, Rachel Toth, John Rouse.   

Abstract

HLTF is highly similar in domain organisation to yeast Rad5. We identify PTIP and RPA70, both involved in DNA replication and DNA repair, as HLTF-interacting proteins although cells depleted of HLTF did not show defects in cellular responses to DNA damage. In vitro, HLTF has ATPase activity and E3 ubiquitin ligase activity with a range of E2 ubiquitin conjugating enzymes. HLTF expression is severely reduced in a range of cancer cells, and we suggest that the HLTF antibodies generated in this study could be used for cancer diagnostic purposes.

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Year:  2009        PMID： 19723507     DOI： 10.1016/j.bbrc.2009.08.151

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  22 in total

1.  RAD5A, RECQ4A, and MUS81 have specific functions in homologous recombination and define different pathways of DNA repair in Arabidopsis thaliana.

Authors:  Anja Mannuss; Stefanie Dukowic-Schulze; Stefanie Suer; Frank Hartung; Michael Pacher; Holger Puchta
Journal:  Plant Cell       Date:  2010-10-22       Impact factor: 11.277

Review 2.  RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response.

Authors:  Alexandre Maréchal; Lee Zou
Journal:  Cell Res       Date:  2014-11-18       Impact factor: 25.617

Review 3.  SMARCAL1 and telomeres: Replicating the troublesome ends.

Authors:  Lisa A Poole; David Cortez
Journal:  Nucleus       Date:  2016-06-29       Impact factor: 4.197

4.  Crystallographic study of a novel DNA-binding domain of human HLTF involved in the template-switching pathway to avoid the replication arrest caused by DNA damage.

Authors:  Yuzu Ikegaya; Kodai Hara; Asami Hishiki; Hideshi Yokoyama; Hiroshi Hashimoto
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-05-20       Impact factor: 1.056

Review 5.  Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.

Authors:  Lisa A Poole; David Cortez
Journal:  Crit Rev Biochem Mol Biol       Date:  2017-09-28       Impact factor: 8.250

6.  Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance.

Authors:  Asami Hishiki; Kodai Hara; Yuzu Ikegaya; Hideshi Yokoyama; Toshiyuki Shimizu; Mamoru Sato; Hiroshi Hashimoto
Journal:  J Biol Chem       Date:  2015-04-09       Impact factor: 5.157

7.  SHORT HYPOCOTYL1 Encodes a SMARCA3-Like Chromatin Remodeling Factor Regulating Elongation.

Authors:  Kailiang Bo; Hui Wang; Yupeng Pan; Tusar K Behera; Sudhakar Pandey; Changlong Wen; Yuhui Wang; Philipp W Simon; Yuhong Li; Jinfeng Chen; Yiqun Weng
Journal:  Plant Physiol       Date:  2016-08-24       Impact factor: 8.340

8.  SMARCAL1 maintains telomere integrity during DNA replication.

Authors:  Lisa A Poole; Runxiang Zhao; Gloria G Glick; Courtney A Lovejoy; Christine M Eischen; David Cortez
Journal:  Proc Natl Acad Sci U S A       Date:  2015-11-17       Impact factor: 11.205

9.  Dynamic elements of replication protein A at the crossroads of DNA replication, recombination, and repair.

Authors:  Colleen C Caldwell; Maria Spies
Journal:  Crit Rev Biochem Mol Biol       Date:  2020-08-28       Impact factor: 8.250

10.  Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.

Authors:  Chi Keung Cheng; Natalie P H Chan; Thomas S K Wan; Lai Ying Lam; Coty H Y Cheung; Terry H Y Wong; Rosalina K L Ip; Raymond S M Wong; Margaret H L Ng
Journal:  Haematologica       Date:  2016-01-22       Impact factor: 9.941
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