Literature DB >> 19723024

Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF).

Janet V Cross1, Joshua M Rady, Frank W Foss, Charles E Lyons, Timothy L Macdonald, Dennis J Templeton.   

Abstract

Dietary ITCs (isothiocyanates) prevent cancer and show other bioactivities in vivo. As electrophiles, ITCs may covalently modify cellular proteins. Using a novel proteomics screen, we identified MIF (macrophage migration inhibitory factor) as the principal target of nutrient ITCs in intact cells. ITCs covalently modify the N-terminal proline residue of MIF and extinguish its catalytic tautomerase activity. MIF deficiency does not prevent induction of Phase 2 gene expression, a hallmark of many cancer chemopreventives, including ITCs. Due to the emerging role of MIF in the control of malignant cell growth and its clear involvement in inflammation, inhibition of MIF by nutrient ITCs suggests therapeutic strategies for inflammatory diseases and cancer.

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Year:  2009        PMID： 19723024      PMCID： PMC2858637          DOI： 10.1042/BJ20091170

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  24 in total

1.  Development of chronic colitis is dependent on the cytokine MIF.

Authors:  Y P de Jong; A C Abadia-Molina; A R Satoskar; K Clarke; S T Rietdijk; W A Faubion; E Mizoguchi; C N Metz; M Alsahli; T ten Hove; A C Keates; J B Lubetsky; R J Farrell; P Michetti; S J van Deventer; E Lolis; J R David; A K Bhan; C Terhorst; M A Sahli
Journal:  Nat Immunol       Date:  2001-11       Impact factor: 25.606

2.  Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.

Authors:  Lingxiang Ye; Albena T Dinkova-Kostova; Kristina L Wade; Yuesheng Zhang; Theresa A Shapiro; Paul Talalay
Journal:  Clin Chim Acta       Date:  2002-02       Impact factor: 3.786

3.  Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.

Authors:  Michael J Campa; Michael Z Wang; Brandon Howard; Michael C Fitzgerald; Edward F Patz
Journal:  Cancer Res       Date:  2003-04-01       Impact factor: 12.701

4.  Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma.

Authors:  Y Ren; H M Chan; J Fan; Y Xie; Y X Chen; W Li; G P Jiang; Q Liu; A Meinhardt; P K H Tam
Journal:  Oncogene       Date:  2006-01-30       Impact factor: 9.867

5.  Macrophage migration inhibitory factor deficiency is associated with altered cell growth and reduced susceptibility to Ras-mediated transformation.

Authors:  Oleksi Petrenko; Gunter Fingerle-Rowson; Tina Peng; Robert A Mitchell; Christine N Metz
Journal:  J Biol Chem       Date:  2003-01-21       Impact factor: 5.157

6.  Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.

Authors:  Yi-Rong Chen; Jin Han; Rajashree Kori; A-N Tony Kong; Tse-Hua Tan
Journal:  J Biol Chem       Date:  2002-08-08       Impact factor: 5.157

7.  Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.

Authors:  Sanjay K Srivastava; Dong Xiao; Karen L Lew; Pamela Hershberger; Demetrius M Kokkinakis; Candace S Johnson; Donald L Trump; Shivendra V Singh
Journal:  Carcinogenesis       Date:  2003-08-01       Impact factor: 4.944

8.  Inhibition of lung tumorigenesis in A/J mice by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine and myo-inositol, individually and in combination.

Authors:  Stephen S Hecht; Pramod Upadhyaya; Mingyao Wang; Robin L Bliss; Edward J McIntee; Patrick M J Kenney
Journal:  Carcinogenesis       Date:  2002-09       Impact factor: 4.944

9.  A proinflammatory cytokine inhibits p53 tumor suppressor activity.

Authors:  J D Hudson; M A Shoaibi; R Maestro; A Carnero; G J Hannon; D H Beach
Journal:  J Exp Med       Date:  1999-11-15       Impact factor: 14.307

10.  Expression of macrophage migration inhibitory factor in human breast cancer: association with nodal spread.

Authors:  Hiroko Bando; Gaku Matsumoto; Masaki Bando; Mariko Muta; Taeko Ogawa; Nobuaki Funata; Jun Nishihira; Morio Koike; Masakazu Toi
Journal:  Jpn J Cancer Res       Date:  2002-04
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  26 in total

1.  Identification of potential protein targets of isothiocyanates by proteomics.

Authors:  Lixin Mi; Brian L Hood; Nicolas A Stewart; Zhen Xiao; Sudha Govind; Xiantao Wang; Thomas P Conrads; Timothy D Veenstra; Fung-Lung Chung
Journal:  Chem Res Toxicol       Date:  2011-08-26       Impact factor: 3.739

2.  Opportunities and challenges for nutritional proteomics in cancer prevention.

Authors:  Donato F Romagnolo; John A Milner
Journal:  J Nutr       Date:  2012-05-30       Impact factor: 4.798

3.  Proteomic analysis of covalent modifications of tubulins by isothiocyanates.

Authors:  Zhen Xiao; Lixin Mi; Fung-Lung Chung; Timothy D Veenstra
Journal:  J Nutr       Date:  2012-05-30       Impact factor: 4.798

4.  Inactivation of tautomerase activity of macrophage migration inhibitory factor by sulforaphane: a potential biomarker for anti-inflammatory intervention.

Authors:  Zachary R Healy; Hua Liu; W David Holtzclaw; Paul Talalay
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2011-05-20       Impact factor: 4.254

5.  Macrophage migration inhibitory factor covalently complexed with phenethyl isothiocyanate.

Authors:  Joel D A Tyndall; Hongqi Lue; Malcolm T Rutledge; Jurgen Bernhagen; Mark B Hampton; Sigurd M Wilbanks
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2012-08-29

Review 6.  Proteins as binding targets of isothiocyanates in cancer prevention.

Authors:  Lixin Mi; Anthony J Di Pasqua; Fung-Lung Chung
Journal:  Carcinogenesis       Date:  2011-06-10       Impact factor: 4.944

7.  In vivo modulation of 4E binding protein 1 (4E-BP1) phosphorylation by watercress: a pilot study.

Authors:  Sharifah S Syed Alwi; Breeze E Cavell; Urvi Telang; Marilyn E Morris; Barbara M Parry; Graham Packham
Journal:  Br J Nutr       Date:  2010-06-15       Impact factor: 3.718

8.  Structural interactions dictate the kinetics of macrophage migration inhibitory factor inhibition by different cancer-preventive isothiocyanates.

Authors:  Gregg V Crichlow; Chengpeng Fan; Camille Keeler; Michael Hodsdon; Elias J Lolis
Journal:  Biochemistry       Date:  2012-09-11       Impact factor: 3.162

Review 9.  Proteomic identification of binding targets of isothiocyanates: A perspective on techniques.

Authors:  Lixin Mi; Zhen Xiao; Timothy D Veenstra; Fung-Lung Chung
Journal:  J Proteomics       Date:  2011-04-30       Impact factor: 4.044

10.  Macrophage migration inhibitory factor promotes tumor growth and metastasis by inducing myeloid-derived suppressor cells in the tumor microenvironment.

Authors:  Kendra D Simpson; Dennis J Templeton; Janet V Cross
Journal:  J Immunol       Date:  2012-11-02       Impact factor: 5.422
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