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Literature DB >> 19719478

The emerging role of the RAB25 small GTPase in cancer.

Roshan Agarwal¹, Igor Jurisica, Gordon B Mills, Kwai Wa Cheng.

Abstract

RAB25, a member of the rat sarcoma (RAS) family of small GTPase, has been implicated in the pathophysiology of ovarian, breast and other cancers. Its role in endosomal transport and recycling of cell-surface receptors and signaling proteins presents a novel paradigm for the disruption of cellular pathways and promotion of tumor development and aggressiveness. Variations in structure and post-translational modifications control the localization of RAS superfamily proteins to specific subcellular compartments and recruitment of downstream effectors, allowing these small GTPases to function as sophisticated modulators of a complex and diverse range of cellular processes. Here, we review the link between RAB25 and tumor development and current knowledge regarding its possible roles in cancer.

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Year: 2009 PMID： 19719478 PMCID： PMC3258497 DOI： 10.1111/j.1600-0854.2009.00969.x

Source DB: PubMed Journal: Traffic ISSN： 1398-9219 Impact factor: 6.215

57 in total

Review 1. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets.

Authors: Panagiotis A Konstantinopoulos; Michalis V Karamouzis; Athanasios G Papavassiliou
Journal: Nat Rev Drug Discov Date: 2007-07 Impact factor: 84.694

2. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

Authors: Patrick T Caswell; Heather J Spence; Maddy Parsons; Dominic P White; Katherine Clark; Kwai Wa Cheng; Gordon B Mills; Martin J Humphries; Anthea J Messent; Kurt I Anderson; Mary W McCaffrey; Bradford W Ozanne; Jim C Norman
Journal: Dev Cell Date: 2007-10 Impact factor: 12.270

3. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.

Authors: Koei Chin; Sandy DeVries; Jane Fridlyand; Paul T Spellman; Ritu Roydasgupta; Wen-Lin Kuo; Anna Lapuk; Richard M Neve; Zuwei Qian; Tom Ryder; Fanqing Chen; Heidi Feiler; Taku Tokuyasu; Chris Kingsley; Shanaz Dairkee; Zhenhang Meng; Karen Chew; Daniel Pinkel; Ajay Jain; Britt Marie Ljung; Laura Esserman; Donna G Albertson; Frederic M Waldman; Joe W Gray
Journal: Cancer Cell Date: 2006-12 Impact factor: 31.743

4. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.

Authors: Yang Fan; Xiao-Yan Xin; Bi-Liang Chen; Xiangdong Ma
Journal: Pathology Date: 2006-12 Impact factor: 5.306

5. In vivo differentiation and genomic evolution in adult male germ cell tumors.

Authors: J E Korkola; S Heck; A B Olshen; V E Reuter; G J Bosl; J Houldsworth; R S K Chaganti
Journal: Genes Chromosomes Cancer Date: 2008-01 Impact factor: 5.006

6. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.

Authors: Roshan Agarwal; Ana-Maria Gonzalez-Angulo; Simen Myhre; Mark Carey; Ju-Seog Lee; Jens Overgaard; Jan Alsner; Katherine Stemke-Hale; Ana Lluch; Richard M Neve; Wen Lin Kuo; Therese Sorlie; Aysegul Sahin; Vicente Valero; Khandan Keyomarsi; Joe W Gray; Anne-Lise Borresen-Dale; Gordon B Mills; Bryan T Hennessy
Journal: Clin Cancer Res Date: 2009-05-26 Impact factor: 12.531

Review 7. Derailed endocytosis: an emerging feature of cancer.

Authors: Yaron Mosesson; Gordon B Mills; Yosef Yarden
Journal: Nat Rev Cancer Date: 2008-11 Impact factor: 60.716

8. Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.

Authors: R Natrajan; R D Williams; S N Hing; A Mackay; J S Reis-Filho; K Fenwick; M Iravani; H Valgeirsson; A Grigoriadis; C F Langford; O Dovey; S G Gregory; B L Weber; A Ashworth; P E Grundy; K Pritchard-Jones; C Jones
Journal: J Pathol Date: 2006-09 Impact factor: 7.996

9. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

Authors: Patrick T Caswell; May Chan; Andrew J Lindsay; Mary W McCaffrey; David Boettiger; Jim C Norman
Journal: J Cell Biol Date: 2008-10-06 Impact factor: 10.539

Review 10. Rab25 in cancer: a brief update.

Authors: Shreya Mitra; Kwai W Cheng; Gordon B Mills
Journal: Biochem Soc Trans Date: 2012-12-01 Impact factor: 5.407

The emerging role of the RAB25 small GTPase in cancer.

Review 1. Post-translational modifications and regulation of the RAS superfamily of GTPases as anticancer targets.

2. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments.

3. Genomic and transcriptional aberrations linked to breast cancer pathophysiologies.

4. Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.

5. In vivo differentiation and genomic evolution in adult male germ cell tumors.

6. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.

Review 7. Derailed endocytosis: an emerging feature of cancer.

8. Array CGH profiling of favourable histology Wilms tumours reveals novel gains and losses associated with relapse.

9. Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

10. Unequal evolutionary conservation of human protein interactions in interologous networks.

1. Increased expression of Rab25 in breast cancer correlates with lymphatic metastasis.

2. Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis.

Review 3. Rab GTPases, membrane trafficking and diseases.

4. Rab25 is overexpressed in Müllerian serous carcinoma compared to malignant mesothelioma.

5. Downregulation of Rab25 activates Akt1 in head and neck squamous cell carcinoma.

6. Rab17 inhibits the tumourigenic properties of hepatocellular carcinomas via the Erk pathway.

Review 7. Rab GTPases implicated in inherited and acquired disorders.

8. Genomic amplicons target vesicle recycling in breast cancer.

9. Expression of Rab25 correlates with the invasion and metastasis of gastric cancer.

Review 10. Rab25 in cancer: a brief update.