Literature DB >> 21561417

Rab GTPases, membrane trafficking and diseases.

Guangpu Li1.   

Abstract

The Rab family of GTPases contains over 60 genes in the human genome and contributes to regulation of intracellular membrane trafficking along endocytic and exocytic pathways as well as specialized pathways in specific cell types. It has become increasingly clear that disruption of the intracellular membrane trafficking system at different stages can cause various diseases. In the past decade, altered expression levels and mutations of Rab GTPases have been associated with such diseases as cancer, Alzheimer's disease, and various genetic disorders. This review discusses the specific Rab GTPases and their involvement in the diseases.

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Year:  2011        PMID： 21561417      PMCID： PMC4260923          DOI： 10.2174/138945011795906561

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  96 in total

1.  Precocious aging and dementia in patients with Down's syndrome.

Authors:  K Wisniewski; J Howe; D G Williams; H M Wisniewski
Journal:  Biol Psychiatry       Date:  1978-10       Impact factor: 13.382

2.  Purification and cloning of amyloid precursor protein beta-secretase from human brain.

Authors:  S Sinha; J P Anderson; R Barbour; G S Basi; R Caccavello; D Davis; M Doan; H F Dovey; N Frigon; J Hong; K Jacobson-Croak; N Jewett; P Keim; J Knops; I Lieberburg; M Power; H Tan; G Tatsuno; J Tung; D Schenk; P Seubert; S M Suomensaari; S Wang; D Walker; J Zhao; L McConlogue; V John
Journal:  Nature       Date:  1999-12-02       Impact factor: 49.962

3.  The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.

Authors:  Kwai Wa Cheng; John P Lahad; Wen-Lin Kuo; Anna Lapuk; Kyosuke Yamada; Nelly Auersperg; Jinsong Liu; Karen Smith-McCune; Karen H Lu; David Fishman; Joe W Gray; Gordon B Mills
Journal:  Nat Med       Date:  2004-10-24       Impact factor: 53.440

Review 4.  Rab7 and the CMT2B disease.

Authors:  Laura Cogli; Francesco Piro; Cecilia Bucci
Journal:  Biochem Soc Trans       Date:  2009-10       Impact factor: 5.407

5.  Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo.

Authors:  Yang Fan; Xiao-Yan Xin; Bi-Liang Chen; Xiangdong Ma
Journal:  Pathology       Date:  2006-12       Impact factor: 5.306

6.  Characterization of the Rab7K157N mutant protein associated with Charcot-Marie-Tooth type 2B.

Authors:  Azzurra De Luca; Cinzia Progida; Maria Rita Spinosa; Pietro Alifano; Cecilia Bucci
Journal:  Biochem Biophys Res Commun       Date:  2008-05-21       Impact factor: 3.575

7.  Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes.

Authors:  Ayae Kinoshita; Hiroaki Fukumoto; Tejal Shah; Christa M Whelan; Michael C Irizarry; Bradley T Hyman
Journal:  J Cell Sci       Date:  2003-06-26       Impact factor: 5.285

8.  RAB23 mutations in Carpenter syndrome imply an unexpected role for hedgehog signaling in cranial-suture development and obesity.

Authors:  Dagan Jenkins; Dominik Seelow; Fernanda S Jehee; Chad A Perlyn; Luis G Alonso; Daniela F Bueno; Dian Donnai; Dragana Josifova; Dragana Josifiova; Irene M J Mathijssen; Jenny E V Morton; Karen Helene Orstavik; Elizabeth Sweeney; Steven A Wall; Jeffrey L Marsh; Peter Nurnberg; Maria Rita Passos-Bueno; Andrew O M Wilkie
Journal:  Am J Hum Genet       Date:  2007-04-18       Impact factor: 11.025

9.  Rab27a enables myosin Va-dependent melanosome capture by recruiting the myosin to the organelle.

Authors:  X Wu; K Rao; M B Bowers; N G Copeland; N A Jenkins; J A Hammer
Journal:  J Cell Sci       Date:  2001-03       Impact factor: 5.285

10.  Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.

Authors:  Patrick T Caswell; May Chan; Andrew J Lindsay; Mary W McCaffrey; David Boettiger; Jim C Norman
Journal:  J Cell Biol       Date:  2008-10-06       Impact factor: 10.539
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  19 in total

1.  Targeted Quantitative Proteomic Approach for High-Throughput Quantitative Profiling of Small GTPases in Brain Tissues of Alzheimer's Disease Patients.

Authors:  Ming Huang; Martin Darvas; C Dirk Keene; Yinsheng Wang
Journal:  Anal Chem       Date:  2019-09-10       Impact factor: 6.986

2.  New insights in the regulation of Rab GTPases by G protein-coupled receptors.

Authors:  Véronik Lachance; Stéphane Angers; Jean-Luc Parent
Journal:  Small GTPases       Date:  2014-05-09

Review 3.  Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.

Authors:  Marcellus J Banworth; Guangpu Li
Journal:  Small GTPases       Date:  2017-12-28

4.  Hypoxia stimulates invasion and migration of human cervical cancer cell lines HeLa/SiHa through the Rab11 trafficking of integrin αvβ3/FAK/PI3K pathway-mediated Rac1 activation.

Authors:  Hao Xu; Yuan Yuan; Wenqian Wu; Min Zhou; Qian Jiang; Linjun Niu; Jiayin Ji; Nianli Liu; Longzhen Zhang; Xia Wang
Journal:  J Biosci       Date:  2017-09       Impact factor: 1.826

5.  Deconvolution of Multiple Rab Binding Domains Using the Batch Yeast 2-Hybrid Method DEEPN.

Authors:  Tabitha A Peterson; Robert C Piper
Journal:  Methods Mol Biol       Date:  2021

Review 6.  G proteins, p60TRP, and neurodegenerative diseases.

Authors:  Klaus Heese
Journal:  Mol Neurobiol       Date:  2013-01-24       Impact factor: 5.590

7.  Association between an insertion/deletion polymorphism within 3'UTR of SGSM3 and risk of hepatocellular carcinoma.

Authors:  Chaoqun Wang; Hua Zhao; Xiankun Zhao; Jiao Wan; Dayong Wang; Wanli Bi; Xinghong Jiang; Yuzhen Gao
Journal:  Tumour Biol       Date:  2013-08-06

8.  Ternary complex structures of human farnesyl pyrophosphate synthase bound with a novel inhibitor and secondary ligands provide insights into the molecular details of the enzyme's active site closure.

Authors:  Jaeok Park; Yih-Shyan Lin; Joris W De Schutter; Youla S Tsantrizos; Albert M Berghuis
Journal:  BMC Struct Biol       Date:  2012-12-12

9.  The small GTPase Rab32 resides on lysosomes to regulate mTORC1 signaling.

Authors:  Kristina Drizyte-Miller; Jing Chen; Hong Cao; Micah B Schott; Mark A McNiven
Journal:  J Cell Sci       Date:  2020-06-11       Impact factor: 5.285

Review 10.  Structural basis of membrane trafficking by Rab family small G protein.

Authors:  Hyun Ho Park
Journal:  Int J Mol Sci       Date:  2013-04-25       Impact factor: 5.923
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