Literature DB >> 1971807

A novel human DNA polymorphism resulting from transfer of DNA from chromosome 6 to chromosome 16.

Z Wong1, N J Royle, A J Jeffreys.   

Abstract

A cloned minisatellite, termed lambda MS29, that is unusual because it detects two variable loci in human DNA has been isolated. One locus, DNF21S1, located in the terminal region of the short arm of human chromosome 6, is also present in great apes. The second minisatellite locus, DNF21S2, is located interstitially on chromosome 16p11 and is absent both from non-human primates and from some humans. Physical mapping and sequencing show that the second locus has arisen recently in evolution by duplication of a large (greater than 15 kb) segment of chromosome 6 DNA containing a minisatellite and transposition onto chromosome 16 into a member of a novel low-copy-number repetitive DNA family. This unusual duplication/transposition event appears to represent the first example of a human DNA polymorphism arising through DNA-mediated, rather than RNA-mediated, transfer between autosomes.

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Year:  1990        PMID： 1971807     DOI： 10.1016/0888-7543(90)90544-5

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  8 in total

1.  Segmental duplications: organization and impact within the current human genome project assembly.

Authors:  J A Bailey; A M Yavor; H F Massa; B J Trask; E E Eichler
Journal:  Genome Res       Date:  2001-06       Impact factor: 9.043

2.  The evolution of tandemly repetitive DNA: recombination rules.

Authors:  R M Harding; A J Boyce; J B Clegg
Journal:  Genetics       Date:  1992-11       Impact factor: 4.562

3.  Analysis of nonuniformity in intron phase distribution.

Authors:  A Fedorov; G Suboch; M Bujakov; L Fedorova
Journal:  Nucleic Acids Res       Date:  1992-05-25       Impact factor: 16.971

4.  Human subtelomeres are hot spots of interchromosomal recombination and segmental duplication.

Authors:  Elena V Linardopoulou; Eleanor M Williams; Yuxin Fan; Cynthia Friedman; Janet M Young; Barbara J Trask
Journal:  Nature       Date:  2005-09-01       Impact factor: 49.962

5.  Characterization of terminal deletions at 7q32 and 22q13.3 healed by De novo telomere addition.

Authors:  H Varley; S Di; S W Scherer; N J Royle
Journal:  Am J Hum Genet       Date:  2000-08-01       Impact factor: 11.025

6.  Global variation in copy number in the human genome.

Authors:  Richard Redon; Shumpei Ishikawa; Karen R Fitch; Lars Feuk; George H Perry; T Daniel Andrews; Heike Fiegler; Michael H Shapero; Andrew R Carson; Wenwei Chen; Eun Kyung Cho; Stephanie Dallaire; Jennifer L Freeman; Juan R González; Mònica Gratacòs; Jing Huang; Dimitrios Kalaitzopoulos; Daisuke Komura; Jeffrey R MacDonald; Christian R Marshall; Rui Mei; Lyndal Montgomery; Kunihiro Nishimura; Kohji Okamura; Fan Shen; Martin J Somerville; Joelle Tchinda; Armand Valsesia; Cara Woodwark; Fengtang Yang; Junjun Zhang; Tatiana Zerjal; Jane Zhang; Lluis Armengol; Donald F Conrad; Xavier Estivill; Chris Tyler-Smith; Nigel P Carter; Hiroyuki Aburatani; Charles Lee; Keith W Jones; Stephen W Scherer; Matthew E Hurles
Journal:  Nature       Date:  2006-11-23       Impact factor: 49.962

Review 7.  The population genetics of structural variation.

Authors:  Donald F Conrad; Matthew E Hurles
Journal:  Nat Genet       Date:  2007-07       Impact factor: 38.330

8.  Increased rate of spontaneous mitotic recombination in T lymphocytes from a Bloom's syndrome patient using a flow-cytometric assay at HLA-A locus.

Authors:  Y Kusunoki; T Hayashi; Y Hirai; J Kushiro; K Tatsumi; T Kurihara; M Zghal; M R Kamoun; H Takebe; A Jeffreys
Journal:  Jpn J Cancer Res       Date:  1994-06
  8 in total

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