| Literature DB >> 19715771 |
Gema Pérez-Chacón1, Alma M Astudillo, David Balgoma, María A Balboa, Jesús Balsinde.
Abstract
Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids, are key mediators of a wide variety of physiological and pathophysiological states. AA, obtained from the diet or synthesized from linoleic acid, is rapidly incorporated into cellular phospholipids by the concerted action of arachidonoyl-CoA synthetase and lysophospholipid acyltransferases. Under the appropriate conditions, AA is liberated from its phospholipid storage sites by the action of one or various phospholipase A(2) enzymes. Thus, cellular availability of AA, and hence the amount of eicosanoids produced, depends on an exquisite balance between phospholipid reacylation and hydrolysis reactions. This review focuses on the enzyme families that are involved in these reactions in resting and stimulated cells.Entities:
Mesh：
Substances：
Year: 2009 PMID： 19715771 DOI： 10.1016/j.bbalip.2009.08.007
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002