Literature DB >> 1971447

Discriminative stimulus properties of 8-OH-DPAT in rats are not altered by pretreatment with para-chlorophenylalanine.

H O Kalkman1.   

Abstract

The role of 5-HT1A autoreceptors in the discriminative stimulus properties of 8-OH-DPAT (0.1 mg/kg, SC) in rats, was investigated. Drug lever appropriate responding to 8-OH-DPAT (0.1 mg/kg, SC) and ipsapirone (3 mg/kg, SC) was measured before and after treatment with para-chlorophenylalanine (pCPA) at a dose (150 mg/kg IP, -3 and -2 days) which causes severe depletion of brain 5-HT stores. The recognition of the drug stimulus was not significantly altered by pCPA. These results indicate that activation of 5-HT1A autoreceptors is of minimal importance to the 8-OH-DPAT cue.

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Year:  1990        PMID： 1971447     DOI： 10.1007/bf02253715

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  22 in total

1.  The narcotic cue: evidence for the specificity of the stimulus properties of narcotic drugs.

Authors:  F C Colpaert; C J Niemegeers; P A Janssen
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-12

2.  Single administration of 5-HT1A agonists decreases 5-HT1A presynaptic, but not postsynaptic receptor-mediated responses: relationship to antidepressant-like action.

Authors:  G A Kennett; M Marcou; C T Dourish; G Curzon
Journal:  Eur J Pharmacol       Date:  1987-06-12       Impact factor: 4.432

3.  Para-chlorophenylalanine prevents feeding induced by the serotonin agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT).

Authors:  C T Dourish; P H Hutson; G Curzon
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

4.  Circadian periodicity of pituitary-adrenal function after p-chlorophenylalanine administration in the rat.

Authors:  A M van Delft; J Kaplanski; P G Smelik
Journal:  J Endocrinol       Date:  1973-12       Impact factor: 4.286

5.  The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat.

Authors:  M D Tricklebank; C Forler; J R Fozard
Journal:  Eur J Pharmacol       Date:  1984-11-13       Impact factor: 4.432

6.  3H-TVX Q 7821: identification of 5-HT1 binding sites as target for a novel putative anxiolytic.

Authors:  W U Dompert; T Glaser; J Traber
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-02       Impact factor: 3.000

7.  Cardiovascular response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) in the rat: site of action and pharmacological analysis.

Authors:  J R Fozard; A K Mir; D N Middlemiss
Journal:  J Cardiovasc Pharmacol       Date:  1987-03       Impact factor: 3.105

8.  Evidence that the hyperphagic response to 8-OH-DPAT is mediated by 5-HT1A receptors.

Authors:  P H Hutson; C T Dourish; G Curzon
Journal:  Eur J Pharmacol       Date:  1988-06-10       Impact factor: 4.432

9.  Discriminative stimulus properties of the 5-HT1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH DPAT).

Authors:  R A Glennon
Journal:  Pharmacol Biochem Behav       Date:  1986-07       Impact factor: 3.533

10.  The effects of a 5-HT1 receptor ligand isapirone (TVX Q 7821) on 5-HT synthesis and the behavioural effects of 5-HT agonists in mice and rats.

Authors:  G M Goodwin; R J De Souza; A R Green
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530
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  3 in total

1.  Discriminative stimulus properties of the 5-HT1A receptor biased agonists NLX-101 and F13714, in rats trained to discriminate 8-OH-DPAT from saline.

Authors:  Jillian H Broadbear; Ronan Y Depoortere; Kristina Vacy; David Ralph; Brendan J Tunstall; Adrian Newman-Tancredi
Journal:  Behav Pharmacol       Date:  2021-12-01       Impact factor: 2.293

2.  Discriminative stimulus properties of 8-OH-DPAT: relationship to affinity for 5HT1A receptors.

Authors:  D J Sanger; H Schoemaker
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

3.  The role of the 5-HT2A and 5-HT2C receptors in the stimulus effects of hallucinogenic drugs. III: The mechanistic basis for supersensitivity to the LSD stimulus following serotonin depletion.

Authors:  D Fiorella; S Helsley; D S Lorrain; R A Rabin; J C Winter
Journal:  Psychopharmacology (Berl)       Date:  1995-10       Impact factor: 4.530
  3 in total

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