BACKGROUND AND OBJECTIVES: Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been limited by the colinearity between UA levels and renal function. Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We investigated the association between UA and renal function progression during the first 3 yr after transplantation, adjusted for baseline renal function, in 1645 patients who were enrolled in the Symphony study. RESULTS: When corrected for baseline renal function, UA levels 1 mo after transplantation were not associated with 3-yr renal function (P = 0.62). There was a strong colinearity between calculated renal function and UA levels 1 mo after transplantation. In fact, when not corrected for baseline renal function, there was a significant association between UA and renal function at 3 yr (P = 0.005). CONCLUSIONS: Low renal function is associated with higher UA levels, but higher UA levels are not independently associated with progression of renal dysfunction after kidney transplantation.
BACKGROUND AND OBJECTIVES:Uric acid (UA) has been linked to renal damage in experimental models of kidney failure. In humans, no definitive link between UA and renal function has been established, but several epidemiologic studies have suggested that higher UA levels are associated with accelerated loss of renal function, higher incidence of dialysis, and death. Many of the associations have been limited by the colinearity between UA levels and renal function. Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: We investigated the association between UA and renal function progression during the first 3 yr after transplantation, adjusted for baseline renal function, in 1645 patients who were enrolled in the Symphony study. RESULTS: When corrected for baseline renal function, UA levels 1 mo after transplantation were not associated with 3-yr renal function (P = 0.62). There was a strong colinearity between calculated renal function and UA levels 1 mo after transplantation. In fact, when not corrected for baseline renal function, there was a significant association between UA and renal function at 3 yr (P = 0.005). CONCLUSIONS: Low renal function is associated with higher UA levels, but higher UA levels are not independently associated with progression of renal dysfunction after kidney transplantation.
Authors: Kirsten A Armstrong; David W Johnson; Scott B Campbell; Nicole M Isbel; Carmel M Hawley Journal: Transplantation Date: 2005-12-15 Impact factor: 4.939
Authors: Henrik Ekberg; Helio Tedesco-Silva; Alper Demirbas; Stefan Vítko; Björn Nashan; Alp Gürkan; Raimund Margreiter; Christian Hugo; Josep M Grinyó; Ulrich Frei; Yves Vanrenterghem; Pierre Daloze; Philip F Halloran Journal: N Engl J Med Date: 2007-12-20 Impact factor: 91.245
Authors: José M Morales; Lars Wramner; Henri Kreis; Dominique Durand; Josep M Campistol; Amado Andres; Joaquin Arenas; Eric Nègre; James T Burke; Carl G Groth Journal: Am J Transplant Date: 2002-05 Impact factor: 8.086
Authors: Michel Chonchol; Michael G Shlipak; Ronit Katz; Mark J Sarnak; Anne B Newman; David S Siscovick; Bryan Kestenbaum; Jan Kirk Carney; Linda F Fried Journal: Am J Kidney Dis Date: 2007-08 Impact factor: 8.860
Authors: Henrique Cotchi Simbo Muela; Jose Jayme Galvão De Lima; Luis Henrique W Gowdak; Flávio J de Paula; Luiz Aparecido Bortolotto Journal: Int J Nephrol Date: 2015-01-22