Literature DB >> 19712947

Cytotoxic ent-kaurane diterpenoids from Isodon sinuolata.

Fei He1, Wei-Lie Xiao, Jian-Xin Pu, Ying-Li Wu, Hai-Bo Zhang, Xiao-Nian Li, Yong Zhao, Li-Bin Yang, Guo-Qiang Chen, Han-Dong Sun.   

Abstract

Five (1-5) ent-kaurane diterpenoids and 17 other known ones, were isolated from the leaves and stems of Isodon sinuolata. Their structures were determined on the basis of spectroscopic methods including 1D and 2D NMR spectroscopic analysis. All compounds were evaluated for cytotoxicity against a small panel of cell lines. Some compounds exhibited significant cytotoxicity.

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Year:  2009        PMID: 19712947     DOI: 10.1016/j.phytochem.2009.07.037

Source DB:  PubMed          Journal:  Phytochemistry        ISSN: 0031-9422            Impact factor:   4.072


  4 in total

1.  Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/caspase, AKT/MAPK and COX-2/NF-κB signaling pathways.

Authors:  Lianzhu Lin; Wuguo Deng; Yun Tian; Wangbing Chen; Jingshu Wang; Lingyi Fu; Dingbo Shi; Mouming Zhao; Wei Luo
Journal:  PLoS One       Date:  2014-05-20       Impact factor: 3.240

2.  A New Human Cancer Cell Proliferation Inhibition Sesquiterpene, Dryofraterpene A, from Medicinal Plant Dryopteris fragrans (L.) Schott.

Authors:  Zheng-Chang Zhong; Dan-Dan Zhao; Zhen-Dong Liu; Shuai Jiang; Yan-Long Zhang
Journal:  Molecules       Date:  2017-01-21       Impact factor: 4.411

3.  Rubesanolides F and G: Two Novel Lactone-Type Norditerpenoids from Isodon rubescens.

Authors:  Kang He; Juan Zou; Yu-Xue Wang; Chen-Liang Zhao; Jiang-Hai Ye; Jing-Jie Zhang; Lu-Tai Pan; Hong-Jie Zhang
Journal:  Molecules       Date:  2021-06-24       Impact factor: 4.411

Review 4.  Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound.

Authors:  Dahong Li; Tong Han; Jie Liao; Xu Hu; Shengtao Xu; Kangtao Tian; Xiaoke Gu; Keguang Cheng; Zhanlin Li; Huiming Hua; Jinyi Xu
Journal:  Int J Mol Sci       Date:  2016-08-24       Impact factor: 5.923

  4 in total

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