Literature DB >> 19711122

Lack of functional relevance of isolated cell damage in transplants of Parkinson's disease patients.

Oliver Cooper1, Arnar Astradsson, Penny Hallett, Harold Robertson, Ivar Mendez, Ole Isacson.   

Abstract

Postmortem analyses from clinical neural transplantation trials of several subjects with Parkinson's disease revealed surviving grafted dopaminergic neurons after more than a decade. A subset of these subjects displayed isolated dopaminergic neurons within the grafts that contained Lewy body-like structures. In this review, we discuss why this isolated cell damage is unlikely to affect the overall graft function and how we can use these observations to help us to understand age-related neurodegeneration and refine our future cell replacement therapies.

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Mesh：

Year:  2009        PMID： 19711122     DOI： 10.1007/s00415-009-5242-z

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  46 in total

1.  Evolution of Parkinson's disease during 4 years of bilateral deep brain stimulation of the subthalamic nucleus.

Authors:  Karen Østergaard; Niels Aa Sunde
Journal:  Mov Disord       Date:  2006-05       Impact factor: 10.338

2.  Cell type-specific gene expression of midbrain dopaminergic neurons reveals molecules involved in their vulnerability and protection.

Authors:  Chee Yeun Chung; Hyemyung Seo; Kai Christian Sonntag; Andrew Brooks; Ling Lin; Ole Isacson
Journal:  Hum Mol Genet       Date:  2005-05-11       Impact factor: 6.150

3.  Age-related changes in dopamine transporters and accumulation of 3-nitrotyrosine in rhesus monkey midbrain dopamine neurons: relevance in selective neuronal vulnerability to degeneration.

Authors:  N M Kanaan; J H Kordower; T J Collier
Journal:  Eur J Neurosci       Date:  2008-06       Impact factor: 3.386

4.  Fetal nigral grafts survive and mediate clinical benefit in a patient with Parkinson's disease.

Authors:  J H Kordower; T B Freeman; E Y Chen; E J Mufson; P R Sanberg; R A Hauser; B Snow; C W Olanow
Journal:  Mov Disord       Date:  1998-05       Impact factor: 10.338

5.  Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.

Authors:  M C Rodriguez-Oroz; J A Obeso; A E Lang; J-L Houeto; P Pollak; S Rehncrona; J Kulisevsky; A Albanese; J Volkmann; M I Hariz; N P Quinn; J D Speelman; J Guridi; I Zamarbide; A Gironell; J Molet; B Pascual-Sedano; B Pidoux; A M Bonnet; Y Agid; J Xie; A-L Benabid; A M Lozano; J Saint-Cyr; L Romito; M F Contarino; M Scerrati; V Fraix; N Van Blercom
Journal:  Brain       Date:  2005-06-23       Impact factor: 13.501

Review 6.  Toward full restoration of synaptic and terminal function of the dopaminergic system in Parkinson's disease by stem cells.

Authors:  Ole Isacson; Lars M Bjorklund; James M Schumacher
Journal:  Ann Neurol       Date:  2003       Impact factor: 10.422

7.  Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease.

Authors:  P Limousin; P Krack; P Pollak; A Benazzouz; C Ardouin; D Hoffmann; A L Benabid
Journal:  N Engl J Med       Date:  1998-10-15       Impact factor: 91.245

8.  Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

Authors:  H Widner; J Tetrud; S Rehncrona; B Snow; P Brundin; B Gustavii; A Björklund; O Lindvall; J W Langston
Journal:  N Engl J Med       Date:  1992-11-26       Impact factor: 91.245

9.  The blood-brain barrier is intact after levodopa-induced dyskinesias in parkinsonian primates--evidence from in vivo neuroimaging studies.

Authors:  Arnar Astradsson; Bruce G Jenkins; Ji-Kyung Choi; Penelope J Hallett; Michele A Levesque; Jack S McDowell; Anna-Liisa Brownell; Roger D Spealman; Ole Isacson
Journal:  Neurobiol Dis       Date:  2009-06-06       Impact factor: 5.996

10.  Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation.

Authors:  Jia-Yi Li; Elisabet Englund; Janice L Holton; Denis Soulet; Peter Hagell; Andrew J Lees; Tammaryn Lashley; Niall P Quinn; Stig Rehncrona; Anders Björklund; Håkan Widner; Tamas Revesz; Olle Lindvall; Patrik Brundin
Journal:  Nat Med       Date:  2008-04-06       Impact factor: 53.440
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  25 in total

Review 1.  Using stem cells and iPS cells to discover new treatments for Parkinson's disease.

Authors:  Oliver Cooper; Penny Hallett; Ole Isacson
Journal:  Parkinsonism Relat Disord       Date:  2012-01       Impact factor: 4.891

2.  Being too inclusive about synuclein inclusions.

Authors:  Ole Isacson; Ivar Mendez
Journal:  Nat Med       Date:  2010-09       Impact factor: 53.440

Review 3.  Parkinson's disease therapeutics: new developments and challenges since the introduction of levodopa.

Authors:  Yoland Smith; Thomas Wichmann; Stewart A Factor; Mahlon R DeLong
Journal:  Neuropsychopharmacology       Date:  2011-09-28       Impact factor: 7.853

4.  Development of histocompatible primate-induced pluripotent stem cells for neural transplantation.

Authors:  Michela Deleidi; Gunnar Hargus; Penelope Hallett; Teresia Osborn; Ole Isacson
Journal:  Stem Cells       Date:  2011-07       Impact factor: 6.277

5.  Lewy Bodies' absence in grafted dopaminergic transplants in Parkinson's Disease.

Authors:  Diana Angelika Olszewska; Tim Lynch
Journal:  Mov Disord Clin Pract       Date:  2015-08-19

Review 6.  A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Authors:  Dominic M Walsh; Dennis J Selkoe
Journal:  Nat Rev Neurosci       Date:  2016-04       Impact factor: 34.870

Review 7.  How strong is the evidence that Parkinson's disease is a prion disorder?

Authors:  Patrik Brundin; Jiyan Ma; Jeffrey H Kordower
Journal:  Curr Opin Neurol       Date:  2016-08       Impact factor: 5.710

Review 8.  Moving stem cells to the clinic: potential and limitations for brain repair.

Authors:  Julius A Steinbeck; Lorenz Studer
Journal:  Neuron       Date:  2015-04-08       Impact factor: 17.173

9.  Relationship of neighboring tissue and gliosis to α-synuclein pathology in a fetal transplant for Parkinson's disease.

Authors:  Tae-Beom Ahn; J William Langston; Venkat Raghav Aachi; Dennis W Dickson
Journal:  Am J Neurodegener Dis       Date:  2012-04-18

Review 10.  Induced pluripotent stem cells and Parkinson's disease: modelling and treatment.

Authors:  Xiaoyun Xu; Jinsha Huang; Jie Li; Ling Liu; Chao Han; Yan Shen; Guoxin Zhang; Haiyang Jiang; Zhicheng Lin; Nian Xiong; Tao Wang
Journal:  Cell Prolif       Date:  2016-01-08       Impact factor: 6.831
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