Literature DB >> 19710292

Investigation on the effect of immune selection on resistance to bactericidal antibodies to group B meningococci in vitro.

George F Santos1, Marzia Giuliani, Laura Santini, Jeanette Adu-Bobie, Mariagrazia Pizza, Rino Rappuoli, William Wacknov, John Donnelly.   

Abstract

The induction of resistance by immune selective pressure to bactericidal antibodies from humans immunized with Novartis recombinant meningococcal group B vaccines was assessed. Serum bactericidal antibody titers against selected bacteria were within assay variability through a selection event frequency of 1 in 10(-5). No change in antigen expression was observed by Western blotting.

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Year:  2009        PMID： 19710292      PMCID： PMC2772378          DOI： 10.1128/CVI.00125-09

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  17 in total

1.  Distribution of surface protein variants among hyperinvasive meningococci: implications for vaccine design.

Authors:  Rachel Urwin; Joanne E Russell; Emily A L Thompson; Edward C Holmes; Ian M Feavers; Martin C J Maiden
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441

2.  Biased distribution of DNA uptake sequences towards genome maintenance genes.

Authors:  Tonje Davidsen; Einar A Rødland; Karin Lagesen; Erling Seeberg; Torbjørn Rognes; Tone Tønjum
Journal:  Nucleic Acids Res       Date:  2004-02-11       Impact factor: 16.971

3.  Interlaboratory standardization of the measurement of serum bactericidal activity by using human complement against meningococcal serogroup b, strain 44/76-SL, before and after vaccination with the Norwegian MenBvac outer membrane vesicle vaccine.

Authors:  Ray Borrow; Ingeborg S Aaberge; George F Santos; T Lynn Eudey; Philipp Oster; Anne Glennie; Jamie Findlow; E Arne Høiby; Einar Rosenqvist; Paul Balmer; Diana Martin
Journal:  Clin Diagn Lab Immunol       Date:  2005-08

4.  A universal vaccine for serogroup B meningococcus.

Authors:  Marzia M Giuliani; Jeannette Adu-Bobie; Maurizio Comanducci; Beatrice Aricò; Silvana Savino; Laura Santini; Brunella Brunelli; Stefania Bambini; Alessia Biolchi; Barbara Capecchi; Elena Cartocci; Laura Ciucchi; Federica Di Marcello; Francesca Ferlicca; Barbara Galli; Enrico Luzzi; Vega Masignani; Davide Serruto; Daniele Veggi; Mario Contorni; Maurizio Morandi; Alessandro Bartalesi; Vanda Cinotti; Donatella Mannucci; Francesca Titta; Elisa Ovidi; Jo Anne Welsch; Dan Granoff; Rino Rappuoli; Mariagrazia Pizza
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-06       Impact factor: 11.205

5.  Neisseria meningitidis group B correlates of protection and assay standardization--international meeting report Emory University, Atlanta, Georgia, United States, 16-17 March 2005.

Authors:  R Borrow; G M Carlone; N Rosenstein; M Blake; I Feavers; D Martin; W Zollinger; J Robbins; I Aaberge; D M Granoff; E Miller; B Plikaytis; L van Alphen; J Poolman; R Rappuoli; L Danzig; J Hackell; B Danve; M Caulfield; S Lambert; D Stephens
Journal:  Vaccine       Date:  2006-06-12       Impact factor: 3.641

6.  Microsatellite instability regulates transcription factor binding and gene expression.

Authors:  Patricia Martin; Katherine Makepeace; Stuart A Hill; Derek W Hood; E Richard Moxon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-22       Impact factor: 11.205

Review 7.  Adaptive evolution of highly mutable loci in pathogenic bacteria.

Authors:  E R Moxon; P B Rainey; M A Nowak; R E Lenski
Journal:  Curr Biol       Date:  1994-01-01       Impact factor: 10.834

8.  Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing.

Authors:  M Pizza; V Scarlato; V Masignani; M M Giuliani; B Aricò; M Comanducci; G T Jennings; L Baldi; E Bartolini; B Capecchi; C L Galeotti; E Luzzi; R Manetti; E Marchetti; M Mora; S Nuti; G Ratti; L Santini; S Savino; M Scarselli; E Storni; P Zuo; M Broeker; E Hundt; B Knapp; E Blair; T Mason; H Tettelin; D W Hood; A C Jeffries; N J Saunders; D M Granoff; J C Venter; E R Moxon; G Grandi; R Rappuoli
Journal:  Science       Date:  2000-03-10       Impact factor: 47.728

9.  Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype.

Authors:  Christopher D Bayliss; J Claire Hoe; Katherine Makepeace; Patricia Martin; Derek W Hood; E Richard Moxon
Journal:  Infect Immun       Date:  2008-08-11       Impact factor: 3.441

10.  Involvement of genes of genome maintenance in the regulation of phase variation frequencies in Neisseria meningitidis.

Authors:  Patricia Martin; Li Sun; Derek W Hood; E Richard Moxon
Journal:  Microbiology       Date:  2004-09       Impact factor: 2.777
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