Literature DB >> 1970797

Linkage analysis of the human HMG14 gene on chromosome 21 using a GT dinucleotide repeat as polymorphic marker.

M B Petersen1, E P Economou, S A Slaugenhaupt, A Chakravarti, S E Antonarakis.   

Abstract

A (GT)n repeat in intron 4 of the functional human HMG14 gene on chromosome 21 was used as polymorphic marker to map this gene relative to the genetic linkage map of human chromosome 21. Variation in the length of the (GT)n repeat was detected by electrophoresis on polyacrylamide gels of DNA amplified by the polymerase chain reaction using primers flanking the repeat. The observed heterozygosity of this polymorphism in 40 CEPH families was 58% with six different alleles. Linkage analysis localized the HMG14 gene close to the ETS2 gene and locus D21S3 in chromosomal band 21q22.3.

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Year:  1990        PMID： 1970797     DOI： 10.1016/0888-7543(90)90531-x

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  23 in total

1.  A contiguous 3-Mb sequence-ready map in the S3-MX region on 21q22.2 based on high- throughput nonisotopic library screenings.

Authors:  T Hildmann; X Kong; J O'Brien; L Riesselman; H M Christensen; E Dagand; H Lehrach; M L Yaspo
Journal:  Genome Res       Date:  1999-04       Impact factor: 9.043

2.  A case of apparent trisomy 21 without the Down's syndrome phenotype.

Authors:  D Avramopoulos; I Kennerknecht; G Barbi; D Eckert; J M Delabar; C Maunoury; A Hallberg; M B Petersen
Journal:  J Med Genet       Date:  1997-07       Impact factor: 6.318

3.  Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.

Authors:  M B Peterson; M Frantzen; S E Antonarakis; A C Warren; C Van Broeckhoven; A Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

Review 4.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

5.  Nondisjunction of chromosome 21: comparisons of cytogenetic and molecular studies of the meiotic stage and parent of origin.

Authors:  B J Lorber; M Grantham; J Peters; H F Willard; T J Hassold
Journal:  Am J Hum Genet       Date:  1992-12       Impact factor: 11.025

6.  DNA polymorphism analysis in families with recurrence of free trisomy 21.

Authors:  C G Pangalos; C C Talbot; J G Lewis; P A Adelsberger; M B Petersen; J L Serre; M O Rethoré; M C de Blois; P Parent; A A Schinzel
Journal:  Am J Hum Genet       Date:  1992-11       Impact factor: 11.025

7.  No evidence for a paternal interchromosomal effect from analysis of the origin of nondisjunction in Down syndrome patients with concomitant familial chromosome rearrangements.

Authors:  A A Schinzel; P A Adelsberger; F Binkert; S Basaran; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

8.  Trisomy 21: association between reduced recombination and nondisjunction.

Authors:  S L Sherman; N Takaesu; S B Freeman; M Grantham; C Phillips; R D Blackston; P A Jacobs; A E Cockwell; V Freeman; I Uchida
Journal:  Am J Hum Genet       Date:  1991-09       Impact factor: 11.025

9.  Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome.

Authors:  M B Petersen; A A Schinzel; F Binkert; L Tranebjaerg; M Mikkelsen; F A Collins; E P Economou; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

Review 10.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957
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