PROBLEM: The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects. METHOD OF STUDY: Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. RESULTS: The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups. CONCLUSION: Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
PROBLEM: The aim of this study was to compare the serum levels of interleukin (IL)-6 of women with unexplained infertility with fertile subjects. METHOD OF STUDY: Serum IL-6, and tumor necrosis factor-alpha (TNF-alpha) levels of 45 infertile and 44 fertile women on day 3 of menstrual cycle were assessed and compared for this prospective controlled study. RESULTS: The mean serum IL-6 level was significantly higher in women with unexplained infertility, compared with fertile women (5.71 +/- 1.81 and 4.31 +/- 1.79, P < 0.001, Student's t-test). There was no significant difference in TNF-alpha level among the groups. CONCLUSION: Significant difference in serum IL-6 levels between unexplained infertile and fertile women suggests that this cytokine may be involved in pathophysiology of unexplained infertility.
Authors: T T Piltonen; J Chen; D W Erikson; T L B Spitzer; F Barragan; J T Rabban; H Huddleston; J C Irwin; L C Giudice Journal: J Clin Endocrinol Metab Date: 2013-07-03 Impact factor: 5.958
Authors: Jacqueline D Kloss; Michael L Perlis; Jessica A Zamzow; Elizabeth J Culnan; Clarisa R Gracia Journal: Sleep Med Rev Date: 2014-10-18 Impact factor: 11.609
Authors: T T Piltonen; J C Chen; M Khatun; M Kangasniemi; A Liakka; T Spitzer; N Tran; H Huddleston; J C Irwin; L C Giudice Journal: Hum Reprod Date: 2015-03-06 Impact factor: 6.918