| Literature DB >> 19700317 |
Kristin A Milinkevich1, Choong L Yoo, Thomas C Sparks, Beth A Lorsbach, Mark J Kurth.
Abstract
Acid hydrazides were coupled with acrylic acid derivatives and cyclodehydration gave 1,3,4-oxadiazoles. Lastly, in-situ nitrile oxide formation from aryl oximes treated with sodium hypochlorite, and subsequent 1,3-dipolar cycloaddition to the exomethylene moiety delivered 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles. This library was evaluated in a high-throughput screen at Dow AgroSciences. Several compounds were active against fungal pathogens and pest insects.Entities:
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Year: 2009 PMID： 19700317 DOI： 10.1016/j.bmcl.2009.07.139
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823