L Pintor1, E Fuente, E Bailles, S Matrai. 1. Psychiatry Department, Neurosciences Institute, Hospital Clínico de Barcelona, C/Roselló 140, 08036 Barcelona, Spain. lpintor@clinic.ub.es
Abstract
PURPOSE: To evaluate the efficacy and safety of amisulpride in medical inpatients who present with delirium. METHOD: Open label prospective study with 7-day follow-up. Forty hospital inpatients with delirium were recruited, seven of whom died and two of whom refused medication. The average dose of amisulpride for delirium treatment was 200-300 mg/day. Daily assessments were performed with Delirium Rating Scale (DRS), Positive Subscale of the Positive and Negative Syndrome Scale (PANSS-P), Mini Mental State Examination (MMSE), Neurological Subscale of the UKU side effect rating scale. Variance analysis was performed through repeated measurements, with the general linear model with paired comparisons and Bonferroni correction for each measured variable. RESULTS: Patients showed significant improvement on the DRS from the first day of treatment DRS = 17.55 until day 7 DRS = 7.26 (F = 92.485; p < 0.001), psychotic symptoms improved from first day PANSS-P = 18.26 to last day PANSS-P = 9.35 (F = 144.83; p < 0.001). Cognitive status showed a significant improvement from day 2 MMSE = 18.71 until day 7 MMSE = 24.06 (F = 96.56; p < 0.001), and the neurological subscale of the UKU side effect rating scale showed a significant improvement the last day with respect to baseline pretreatment level (F = 7.539; p = 0.01). CONCLUSIONS: These results suggest a good response to amisulpride in the acute phase of delirium, although further randomized controlled studies must be performed.
RCT Entities:
PURPOSE: To evaluate the efficacy and safety of amisulpride in medical inpatients who present with delirium. METHOD: Open label prospective study with 7-day follow-up. Forty hospital inpatients with delirium were recruited, seven of whom died and two of whom refused medication. The average dose of amisulpride for delirium treatment was 200-300 mg/day. Daily assessments were performed with Delirium Rating Scale (DRS), Positive Subscale of the Positive and Negative Syndrome Scale (PANSS-P), Mini Mental State Examination (MMSE), Neurological Subscale of the UKU side effect rating scale. Variance analysis was performed through repeated measurements, with the general linear model with paired comparisons and Bonferroni correction for each measured variable. RESULTS:Patients showed significant improvement on the DRS from the first day of treatment DRS = 17.55 until day 7 DRS = 7.26 (F = 92.485; p < 0.001), psychotic symptoms improved from first day PANSS-P = 18.26 to last day PANSS-P = 9.35 (F = 144.83; p < 0.001). Cognitive status showed a significant improvement from day 2 MMSE = 18.71 until day 7 MMSE = 24.06 (F = 96.56; p < 0.001), and the neurological subscale of the UKU side effect rating scale showed a significant improvement the last day with respect to baseline pretreatment level (F = 7.539; p = 0.01). CONCLUSIONS: These results suggest a good response to amisulpride in the acute phase of delirium, although further randomized controlled studies must be performed.
Authors: Luigi Grassi; Augusto Caraceni; Alex J Mitchell; Maria Giulia Nanni; Maria Alejandra Berardi; Rosangela Caruso; Michelle Riba Journal: Curr Psychiatry Rep Date: 2015-03 Impact factor: 5.285
Authors: José G Franco; Juan Carlos Molano; Hernán Rincón; Juan David Velasquez Tirado; Carlos Cardeño; Liliana Patarroyo Rodriguez; Gabriel Fernando Oviedo Lugo; Jaime Bernal Miranda; Monica Rojas Moreno Journal: Rev Colomb Psiquiatr (Engl Ed) Date: 2020-12-02
Authors: José G Franco; Juan Carlos Molano; Hernán Rincón; Juan David Velasquez Tirado; Carlos Cardeño; Liliana Patarroyo Rodriguez; Gabriel Fernando Oviedo Lugo; Jaime Bernal Miranda; Monica Rojas Moreno Journal: Rev Colomb Psiquiatr (Engl Ed) Date: 2022-09-01