PURPOSE: Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and electrical stimulation of the human insular cortex during invasive evaluation of epileptic patients. METHODS: We evaluated 25 patients who had drug refractory focal epilepsy with at least one electrode stereotactically implanted in the insular cortex. RESULTS: Eight responses to insular cortex electrical stimulation were reported by five patients as speech arrest (five responses) and a lowering of voice intensity (three responses). CONCLUSIONS: Data from this study implicate the middle short gyrus of the insula in the production of speech and show the importance of intrainsular electrode implantation during invasive pre-resection evaluation by stereo-electroencephalography (SEEG) when speech arrest occurs early in seizure semiology.
PURPOSE: Different lines of evidence have suggested an involvement of the insular cortex in speech production. These have included results from lesion studies, functional imaging techniques, and electrical stimulation of the human insular cortex during invasive evaluation of epilepticpatients. METHODS: We evaluated 25 patients who had drug refractory focal epilepsy with at least one electrode stereotactically implanted in the insular cortex. RESULTS: Eight responses to insular cortex electrical stimulation were reported by five patients as speech arrest (five responses) and a lowering of voice intensity (three responses). CONCLUSIONS: Data from this study implicate the middle short gyrus of the insula in the production of speech and show the importance of intrainsular electrode implantation during invasive pre-resection evaluation by stereo-electroencephalography (SEEG) when speech arrest occurs early in seizure semiology.
Authors: Corey J Keller; Christopher J Honey; Pierre Mégevand; Laszlo Entz; Istvan Ulbert; Ashesh D Mehta Journal: Philos Trans R Soc Lond B Biol Sci Date: 2014-10-05 Impact factor: 6.237
Authors: Brian Ervin; Jason Buroker; Anna W Byars; Leonid Rozhkov; James L Leach; Paul S Horn; Craig Scholle; Francesco T Mangano; Hansel M Greiner; Katherine D Holland; Tracy A Glauser; Ravindra Arya Journal: Clin Neurophysiol Date: 2021-09-30 Impact factor: 3.708