Brian Ervin1, Jason Buroker2, Anna W Byars3, Leonid Rozhkov2, James L Leach4, Paul S Horn3, Craig Scholle2, Francesco T Mangano5, Hansel M Greiner3, Katherine D Holland3, Tracy A Glauser3, Ravindra Arya6. 1. Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio, USA. 2. Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 3. Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. 4. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Division of Pediatric Neuro-radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 5. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Division of Pediatric Neurosurgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. 6. Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA; Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. Electronic address: Ravindra.Arya@cchmc.org.
Abstract
OBJECTIVE: Cerebral spatiotemporal dynamics of visual naming were investigated in epilepsy patients undergoing stereo-electroencephalography (SEEG) monitoring. METHODS: Brain networks were defined by Parcel-Activation-Resection-Symptom matching (PARS) approach by matching high-gamma (50-150 Hz) modulations (HGM) in neuroanatomic parcels during visual naming, with neuropsychological outcomes after resection/ablation of those parcels. Brain parcels with >50% electrode contacts simultaneously showing significant HGM were aligned, to delineate spatiotemporal course of naming-related HGM. RESULTS: In 41 epilepsy patients, neuroanatomic parcels showed sequential yet temporally overlapping HGM course during visual naming. From bilateral occipital lobes, HGM became increasingly left lateralized, coursing through limbic system. Bilateral superior temporal HGM was noted around response time, and right frontal HGM thereafter. Correlations between resected/ablated parcels, and post-surgical neuropsychological outcomes showed specific regional groupings. CONCLUSIONS: Convergence of data from spatiotemporal course of HGM during visual naming, and functional role of specific parcels inferred from neuropsychological deficits after resection/ablation of those parcels, support a model with six cognitive subcomponents of visual naming having overlapping temporal profiles. SIGNIFICANCE: Cerebral substrates supporting visual naming are bilaterally distributed with relative hemispheric contribution dependent on cognitive demands at a specific time. PARS approach can be extended to study other cognitive and functional brain networks.
OBJECTIVE: Cerebral spatiotemporal dynamics of visual naming were investigated in epilepsy patients undergoing stereo-electroencephalography (SEEG) monitoring. METHODS: Brain networks were defined by Parcel-Activation-Resection-Symptom matching (PARS) approach by matching high-gamma (50-150 Hz) modulations (HGM) in neuroanatomic parcels during visual naming, with neuropsychological outcomes after resection/ablation of those parcels. Brain parcels with >50% electrode contacts simultaneously showing significant HGM were aligned, to delineate spatiotemporal course of naming-related HGM. RESULTS: In 41 epilepsy patients, neuroanatomic parcels showed sequential yet temporally overlapping HGM course during visual naming. From bilateral occipital lobes, HGM became increasingly left lateralized, coursing through limbic system. Bilateral superior temporal HGM was noted around response time, and right frontal HGM thereafter. Correlations between resected/ablated parcels, and post-surgical neuropsychological outcomes showed specific regional groupings. CONCLUSIONS: Convergence of data from spatiotemporal course of HGM during visual naming, and functional role of specific parcels inferred from neuropsychological deficits after resection/ablation of those parcels, support a model with six cognitive subcomponents of visual naming having overlapping temporal profiles. SIGNIFICANCE: Cerebral substrates supporting visual naming are bilaterally distributed with relative hemispheric contribution dependent on cognitive demands at a specific time. PARS approach can be extended to study other cognitive and functional brain networks.
Authors: Ravindra Arya; Celie Roth; James L Leach; Denise Middeler; J Adam Wilson; Jennifer Vannest; Leonid Rozhkov; Hansel M Greiner; Jason Buroker; Craig Scholle; Hisako Fujiwara; Paul S Horn; Douglas F Rose; Nathan E Crone; Francesco T Mangano; Anna W Byars; Katherine D Holland Journal: Epilepsy Res Date: 2019-01-29 Impact factor: 3.045
Authors: Ravindra Arya; J Adam Wilson; Hisako Fujiwara; Leonid Rozhkov; James L Leach; Anna W Byars; Hansel M Greiner; Jennifer Vannest; Jason Buroker; Griffin Milsap; Brian Ervin; Ali Minai; Paul S Horn; Katherine D Holland; Francesco T Mangano; Nathan E Crone; Douglas F Rose Journal: Epilepsia Date: 2017-02-22 Impact factor: 5.864
Authors: Kiefer James Forseth; Cihan Mehmet Kadipasaoglu; Christopher Richard Conner; Gregory Hickok; Robert Thomas Knight; Nitin Tandon Journal: Brain Date: 2018-07-01 Impact factor: 13.501
Authors: Ravindra Arya; Brian Ervin; Jason Buroker; Hansel M Greiner; Anna W Byars; Leonid Rozhkov; Jesse Skoch; Paul S Horn; Clayton Frink; Craig Scholle; James L Leach; Francesco T Mangano; Tracy A Glauser; Katherine D Holland Journal: Front Neurosci Date: 2022-05-19 Impact factor: 5.152