| Literature DB >> 19693451 |
Natsue Igarashi1, Takaaki Chou2, Takayuki Hirose2, Yousuke Imai2, Takuro Ishiguro2, Keiichi Nemoto3.
Abstract
Donor cell leukemia (DCL) is a rare, but well-known, complication after allogeneic hematopoietic cell transplantation. We report a case of donor cell-derived acute lymphocytic leukemia (ALL) occurring in a 55-year-old man after allogeneic bone marrow transplantation (allo-BMT) from an HLA-matched unrelated donor for refractory multiple myeloma (MM). Molecular analysis using short tandem repeat sequences proved the ALL to be of donor origin. He underwent combination chemotherapy and second allo-BMT from an alternative donor. After second allo-BMT, extramedullary myeloma relapsed as tumor, but was successfully treated with proteasome inhibitor, bortezomib. However, he died from severe graft-versus-host disease four months after the second transplantation. Although more than 50 cases of DCL have been reported, there have been only two reports of DCL developed in MM patients including our case. This rare complication may give some insights into leukemogenesis.Entities:
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Year: 2009 PMID： 19693451 DOI： 10.1007/s12185-009-0397-z
Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490