| Literature DB >> 19692269 |
Myew-Ling Toh1, Masanori Kawashima, Saloua Zrioual, Arnaud Hot, Philippe Miossec, Pierre Miossec.
Abstract
Th17 cells are critical in adaptive immunity and autoimmune disease. The polarized development of Th17, Th1 and Th2 cells is dependent on counterregulatory effects on each other. Whereas IFN-gamma inhibits Th17 development, the effect of IL-17 in human Th1 development is not known. We report a novel negative regulatory role of IL-17 on IL-12R beta 2 expression associated with reduced IL-12 responsiveness. IL-17 decreased IL-12-induced IFN-gamma expression in PBMC and developing Th1 cells, associated with a selective reduction in IL-12R beta 2, and not IL-23R, IL-12R beta 1 or T-bet. Counterregulatory effects of human Th17 on Th1 lineage cytokines may contribute to lineage divergence. In autoimmune disease, IL-17 may reinforce its own developmental programme by reducing IL-12 responsiveness, thus limiting inhibitory effects of IFN-gamma on Th17 development.Entities:
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Year: 2009 PMID： 19692269 DOI： 10.1016/j.cyto.2009.07.013
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861