Literature DB >> 19690533

Taking the chemical out of chemical genetics.

Charles P Scott1.   

Abstract

Screening a library of expressed cyclic peptides identified clones that reverse the cytotoxicity of alpha-synuclein in yeast and Caenorhabditis elegans. The results suggest a new approach for intervention in Parkinson's disease, and perhaps a druggable target.

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Year:  2009        PMID： 19690533     DOI： 10.1038/nchembio0909-609

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  10 in total

1.  Retrovirally delivered random cyclic Peptide libraries yield inhibitors of interleukin-4 signaling in human B cells.

Authors:  Todd M Kinsella; Cara T Ohashi; Amy Grace Harder; George C Yam; Weiqun Li; Beau Peelle; Erlina S Pali; Mark K Bennett; Susan M Molineaux; D A Anderson; Esteban S Masuda; Donald G Payan
Journal:  J Biol Chem       Date:  2002-07-11       Impact factor: 5.157

Review 2.  Trends in development and approval times for new therapeutics in the United States.

Authors:  Janice M Reichert
Journal:  Nat Rev Drug Discov       Date:  2003-09       Impact factor: 84.694

Review 3.  The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy.

Authors:  Alessandra Gaeta; Robert C Hider
Journal:  Br J Pharmacol       Date:  2005-12       Impact factor: 8.739

Review 4.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

5.  Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models.

Authors:  Antony A Cooper; Aaron D Gitler; Anil Cashikar; Cole M Haynes; Kathryn J Hill; Bhupinder Bhullar; Kangning Liu; Kexiang Xu; Katherine E Strathearn; Fang Liu; Songsong Cao; Kim A Caldwell; Guy A Caldwell; Gerald Marsischky; Richard D Kolodner; Joshua Labaer; Jean-Christophe Rochet; Nancy M Bonini; Susan Lindquist
Journal:  Science       Date:  2006-06-22       Impact factor: 47.728

6.  Chemical genetics: where genetics and pharmacology meet.

Authors:  Zachary A Knight; Kevan M Shokat
Journal:  Cell       Date:  2007-02-09       Impact factor: 41.582

7.  Alpha-synuclein in Lewy bodies.

Authors:  M G Spillantini; M L Schmidt; V M Lee; J Q Trojanowski; R Jakes; M Goedert
Journal:  Nature       Date:  1997-08-28       Impact factor: 49.962

8.  Structural requirements for the biosynthesis of backbone cyclic peptide libraries.

Authors:  C P Scott; E Abel-Santos; A D Jones; S J Benkovic
Journal:  Chem Biol       Date:  2001-08

9.  Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.

Authors:  Joshua A Kritzer; Shusei Hamamichi; J Michael McCaffery; Sandro Santagata; Todd A Naumann; Kim A Caldwell; Guy A Caldwell; Susan Lindquist
Journal:  Nat Chem Biol       Date:  2009-07-13       Impact factor: 15.040

10.  Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity.

Authors:  Aaron D Gitler; Alessandra Chesi; Melissa L Geddie; Katherine E Strathearn; Shusei Hamamichi; Kathryn J Hill; Kim A Caldwell; Guy A Caldwell; Antony A Cooper; Jean-Christophe Rochet; Susan Lindquist
Journal:  Nat Genet       Date:  2009-02-01       Impact factor: 38.330
  10 in total

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