Literature DB >> 19690531

Protease dimer formation disrupted.

Jean Chmielewski1.   

Abstract

A small-molecule inhibitor of the obligate dimeric protease of human Kaposi's sarcoma-associated herpesvirus was identified. The agent functions by a "monomer trap" mechanism in which the compound binds to a partially unfolded monomer and disrupts the formation of the enzymatically active protease dimer.

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Year:  2009        PMID： 19690531     DOI： 10.1038/nchembio0909-607

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  6 in total

Review 1.  Scaffolds for blocking protein-protein interactions.

Authors:  Stefan J Hershberger; Song-Gil Lee; Jean Chmielewski
Journal:  Curr Top Med Chem       Date:  2007       Impact factor: 3.295

Review 2.  Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

Authors:  James A Wells; Christopher L McClendon
Journal:  Nature       Date:  2007-12-13       Impact factor: 49.962

Review 3.  Principles of protein-protein interactions.

Authors:  S Jones; J M Thornton
Journal:  Proc Natl Acad Sci U S A       Date:  1996-01-09       Impact factor: 11.205

4.  Functional consequences of the Kaposi's sarcoma-associated herpesvirus protease structure: regulation of activity and dimerization by conserved structural elements.

Authors:  K K Reiling; T R Pray; C S Craik; R M Stroud
Journal:  Biochemistry       Date:  2000-10-24       Impact factor: 3.162

5.  Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments.

Authors:  Thomas D Wu; Celia A Schiffer; Matthew J Gonzales; Jonathan Taylor; Rami Kantor; Sunwen Chou; Dennis Israelski; Andrew R Zolopa; W Jeffrey Fessel; Robert W Shafer
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

6.  Inhibition of a viral enzyme by a small-molecule dimer disruptor.

Authors:  Tina Shahian; Gregory M Lee; Ana Lazic; Leggy A Arnold; Priya Velusamy; Christina M Roels; R Kiplin Guy; Charles S Craik
Journal:  Nat Chem Biol       Date:  2009-07-26       Impact factor: 15.040
  6 in total

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