PURPOSE: The ability to evaluate clinicopathologic features and prognosis before surgery by contrast-enhanced CT would be valuable for managing rectal cancer. This study was designed to evaluate the clinical usefulness of perfusion CT in patients with rectal cancer before surgery. METHODS: Forty-four consecutive patients (27 men, 17 women; median age, 63.6 years) with rectal cancer underwent perfusion CT before surgery. We retrospectively investigated the correlations between tumor blood flow generated by perfusion CT and clinicopathologic features. RESULTS: There was a significant correlation between blood flow and wall invasion (P = 0.04). Well-differentiated tumors showed significantly higher blood flow than moderately differentiated tumors (P = 0.03). There was a significant tendency for tumors with low blood flow to show lymph node metastasis (P = 0.0005), vascular invasion (P = 0.004), lymphatic invasion (P = 0.04), and distant metastasis (P = 0.0005). For blood flow, accuracy was 75% for detection of tumors with lymph node metastasis if the cutoff point was set at 55 ml/100 g per minute. Patients with high blood flow tumors survived significantly longer than those with low blood flow tumors (P = 0.002). CONCLUSIONS: Blood flow of rectal cancers may be useful to evaluate pathologic features and prognosis before surgery.
PURPOSE: The ability to evaluate clinicopathologic features and prognosis before surgery by contrast-enhanced CT would be valuable for managing rectal cancer. This study was designed to evaluate the clinical usefulness of perfusion CT in patients with rectal cancer before surgery. METHODS: Forty-four consecutive patients (27 men, 17 women; median age, 63.6 years) with rectal cancer underwent perfusion CT before surgery. We retrospectively investigated the correlations between tumor blood flow generated by perfusion CT and clinicopathologic features. RESULTS: There was a significant correlation between blood flow and wall invasion (P = 0.04). Well-differentiated tumors showed significantly higher blood flow than moderately differentiated tumors (P = 0.03). There was a significant tendency for tumors with low blood flow to show lymph node metastasis (P = 0.0005), vascular invasion (P = 0.004), lymphatic invasion (P = 0.04), and distant metastasis (P = 0.0005). For blood flow, accuracy was 75% for detection of tumors with lymph node metastasis if the cutoff point was set at 55 ml/100 g per minute. Patients with high blood flow tumors survived significantly longer than those with low blood flow tumors (P = 0.002). CONCLUSIONS: Blood flow of rectal cancers may be useful to evaluate pathologic features and prognosis before surgery.
Authors: Vicky Goh; Manu Shastry; Alec Engledow; Jonathan Reston; David M Wellsted; Jacqui Peck; Raymondo Endozo; Manuel Rodriguez-Justo; Stuart A Taylor; Steve Halligan; Ashley M Groves Journal: Eur Radiol Date: 2010-10-05 Impact factor: 5.315
Authors: Manish Chand; Deborah S Keller; Reza Mirnezami; Marc Bullock; Aneel Bhangu; Brendan Moran; Paris P Tekkis; Gina Brown; Alexander Mirnezami; Mariana Berho Journal: World J Gastrointest Oncol Date: 2018-07-15