Literature DB >> 19688745

Why Aire? Compensating for late bloomers.

Melvin Cohn1.   

Abstract

The question under analysis in this commentary is, what was the evolutionary selection pressure that necessitated the ectopic expression of a subset of peripheral self-antigens in the thymus and by peripheral APC? The suggestion is that antigen expression is delayed until after the immune system is responsive.

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Year:  2009        PMID： 19688745      PMCID： PMC2869625          DOI： 10.1002/eji.200939628

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  25 in total

1.  A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). I. The origin of 'primer' effector T(h) cells.

Authors:  Melvin Cohn; Rodney E Langman; James J Mata
Journal:  Int Immunol       Date:  2002-10       Impact factor: 4.823

2.  A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). II. The behavior of the system upon encounter with non-self antigens.

Authors:  Rodney E Langman; James J Mata; Melvin Cohn
Journal:  Int Immunol       Date:  2003-05       Impact factor: 4.823

Review 3.  Self-representation in the thymus: an extended view.

Authors:  Bruno Kyewski; Jens Derbinski
Journal:  Nat Rev Immunol       Date:  2004-09       Impact factor: 53.106

Review 4.  The self/nonself discrimination: reconstructing a cabbage from sauerkraut.

Authors:  M Cohn
Journal:  Res Immunol       Date:  1992 Mar-Apr

5.  Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular input.

Authors:  Andrea J White; David R Withers; Sonia M Parnell; Hamish S Scott; Daniela Finke; Peter J L Lane; Eric J Jenkinson; Graham Anderson
Journal:  Eur J Immunol       Date:  2008-04       Impact factor: 5.532

6.  Tolerance induced by thymic epithelial grafts in birds.

Authors:  H Ohki; C Martin; C Corbel; M Coltey; N M Le Douarin
Journal:  Science       Date:  1987-08-28       Impact factor: 47.728

7.  Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells.

Authors:  T E Adams; S Alpert; D Hanahan
Journal:  Nature       Date:  1987 Jan 15-21       Impact factor: 49.962

8.  How does the immune response get started?

Authors:  Melvin Cohn
Journal:  Cell Immunol       Date:  2008-11-20       Impact factor: 4.868

9.  Neonatal tolerance revisited: a perinatal window for Aire control of autoimmunity.

Authors:  Mireia Guerau-de-Arellano; Marianne Martinic; Christophe Benoist; Diane Mathis
Journal:  J Exp Med       Date:  2009-06-01       Impact factor: 14.307

10.  Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.

Authors:  Jörn Gotter; Benedikt Brors; Manfred Hergenhahn; Bruno Kyewski
Journal:  J Exp Med       Date:  2004-01-19       Impact factor: 14.307
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  8 in total

1.  Ten experiments that would make a difference in understanding immune mechanisms.

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2011-11-01       Impact factor: 9.261

2.  Analysis of Paris meeting redefining the "self" of the immune system.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2015-05       Impact factor: 2.829

Review 3.  Learning from a contemporary history of immunology.

Authors:  Melvin Cohn
Journal:  Immunol Res       Date:  2017-06       Impact factor: 2.829

4.  The evolutionary context for a self-nonself discrimination.

Authors:  Melvin Cohn
Journal:  Cell Mol Life Sci       Date:  2010-06-24       Impact factor: 9.261

Review 5.  Expression of the autoimmune regulator gene and its relevance to the mechanisms of central and peripheral tolerance.

Authors:  Roberto Perniola
Journal:  Clin Dev Immunol       Date:  2012-10-22

Review 6.  Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients.

Authors:  Kai Kisand; Pärt Peterson; Martti Laan
Journal:  Front Immunol       Date:  2014-02-13       Impact factor: 7.561

Review 7.  Serial progression of cortical and medullary thymic epithelial microenvironments.

Authors:  Nuno L Alves; Yousuke Takahama; Izumi Ohigashi; Ana R Ribeiro; Song Baik; Graham Anderson; William E Jenkinson
Journal:  Eur J Immunol       Date:  2013-12-04       Impact factor: 5.532

Review 8.  Twenty Years of AIRE.

Authors:  Roberto Perniola
Journal:  Front Immunol       Date:  2018-02-12       Impact factor: 7.561
  8 in total

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