Literature DB >> 3543686

Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells.

T E Adams, S Alpert, D Hanahan.   

Abstract

Transgenic mice expressing simian virus 40 T antigen under control of the insulin gene regulatory region vary in their response to this protein. Each lineage is characteristically either tolerant to T antigen, or not, in which case autoantibodies arise with high frequency, and lymphocytes infiltrate and disrupt the pancreatic islets. Both non-tolerance and the autoimmune response appear to result from delayed onset of T antigen expression during beta cell development.

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Year:  1987        PMID： 3543686     DOI： 10.1038/325223a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  54 in total

1.  A computerized model for the self-non-self discrimination at the level of the T(h) (Th genesis). II. The behavior of the system upon encounter with non-self antigens.

Authors:  Rodney E Langman; James J Mata; Melvin Cohn
Journal:  Int Immunol       Date:  2003-05       Impact factor: 4.823

Review 2.  Autoimmune diabetes and the germ theory of disease.

Authors:  T J Wilkin
Journal:  Diabetologia       Date:  1992-02       Impact factor: 10.122

3.  Mice transgenic for a vasopressin-SV40 hybrid oncogene develop tumors of the endocrine pancreas and the anterior pituitary. A possible model for human multiple endocrine neoplasia type 1.

Authors:  D Murphy; A Bishop; G Rindi; M N Murphy; G W Stamp; J Hanson; J M Polak; B Hogan
Journal:  Am J Pathol       Date:  1987-12       Impact factor: 4.307

4.  A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice.

Authors:  G Rindi; A E Bishop; D Murphy; E Solcia; B Hogan; J M Polak
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1988

5.  Developmental failure of chimeric embryos expressing high levels of H-2Dd transplantation antigens.

Authors:  L Jaffe; E J Robertson; E K Bikoff
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-01       Impact factor: 11.205

Review 6.  On the responses of Zinkernagel and Hengartner: an invitation to join the fray.

Authors:  M Cohn
Journal:  Scand J Immunol       Date:  2005-07       Impact factor: 3.487

Review 7.  Does the signal for the activation of T cells originate from the antigen-presenting cell or the effector T-helper?

Authors:  Melvin Cohn
Journal:  Cell Immunol       Date:  2006-09-11       Impact factor: 4.868

Review 8.  Control of self-reactivity in the intestine.

Authors:  T A Barrett; S M Hedrick; A L Dent; M L Delvy; D M Kennedy; L A Matis; J A Bluestone
Journal:  Immunol Res       Date:  1991       Impact factor: 2.829

Review 9.  I-E transgenic mice: a model system to dissect the regulation and function of MHC class II genes in vivo.

Authors:  L C Burkly; D Lo; R L Brinster; R A Flavell
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

10.  The milk protein promoter is a useful tool for developing a rat with tolerance to a human protein.

Authors:  R Takahashi; M Ueda
Journal:  Transgenic Res       Date:  2001-12       Impact factor: 2.788
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