| Literature DB >> 19686677 |
Abstract
The transcription factor BLIMP1 is a master regulator of primordial germ cell (PGC) specification and is suppressed by the microRNA let-7. In a recent issue of Nature, West and colleagues use a unique in vitro ES cell differentiation strategy to show that LIN28 is an essential regulator of PGC formation through inhibition of let-7 maturation and consequential induction of BLIMP1.Entities:
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Year: 2009 PMID: 19686677 DOI: 10.1016/j.devcel.2009.07.020
Source DB: PubMed Journal: Dev Cell ISSN: 1534-5807 Impact factor: 12.270