| Literature DB >> 1968506 |
M Polydefkis1, S Koenig, C Flexner, E Obah, K Gebo, S Chakrabarti, P L Earl, B Moss, R F Siliciano.
Abstract
Human CD4+ T cell clones and cell lines were shown to lyse recombinant vaccinia virus-infected cells that synthesize the HIV-1 envelope glycoprotein gp160. The processing of endogenously synthesized gp160 for recognition by CD4+ T cells required that the protein, after synthesis on the rough endoplasmic reticulum and during subsequent cellular transport, remain attached to the luminal/extracellular membrane face by a hydrophobic anchor sequence.Entities:
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Year: 1990 PMID: 1968506 PMCID: PMC2187764 DOI: 10.1084/jem.171.3.875
Source DB: PubMed Journal: J Exp Med ISSN: 0022-1007 Impact factor: 14.307