Literature DB >> 3014647

Neutralization of the AIDS retrovirus by antibodies to a recombinant envelope glycoprotein.

L A Lasky, J E Groopman, C W Fennie, P M Benz, D J Capon, D J Dowbenko, G R Nakamura, W M Nunes, M E Renz, P W Berman.   

Abstract

Mammalian cell lines have been engineered to produce a secreted form of the AIDS retrovirus envelope glycoprotein. The recombinant protein has been isolated from growth-conditioned culture media and used to immunize animals. Antibodies directed against the recombinant molecule were found to react with the envelope glycoprotein produced in virus-infected cells. Furthermore, these antibodies were able to directly inactivate the AIDS retrovirus in a neutralization assay in vitro. The expression system reported here should provide sufficient quantities of the AIDS retrovirus envelope protein for biological and vaccination studies.

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Year:  1986        PMID： 3014647     DOI： 10.1126/science.3014647

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  131 in total

1.  Cellular membrane-binding ability of the C-terminal cytoplasmic domain of human immunodeficiency virus type 1 envelope transmembrane protein gp41.

Authors:  S S Chen; S F Lee; C T Wang
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

2.  CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.

Authors:  B Crise; L Buonocore; J K Rose
Journal:  J Virol       Date:  1990-11       Impact factor: 5.103

3.  Lessons in nonhuman primate models for AIDS vaccine research: from minefields to milestones.

Authors:  Jeffrey D Lifson; Nancy L Haigwood
Journal:  Cold Spring Harb Perspect Med       Date:  2012-06       Impact factor: 6.915

4.  Coexpression of human immunodeficiency virus envelope proteins and tat from a single simian virus 40 late replacement vector.

Authors:  D Rekosh; A Nygren; P Flodby; M L Hammarskjöld; H Wigzell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-01       Impact factor: 11.205

5.  Production of a recombinant monoclonal antibody to Herpes Simplex Virus glycoprotein D for immunoaffinity purification of tagged proteins.

Authors:  Sara M O'Rourke; Bin Yu; Javier F Morales; Chelsea M Didinger; David L Alexander; Christopher Vollmers; Phillip W Berman
Journal:  J Immunol Methods       Date:  2018-11-28       Impact factor: 2.303

6.  Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.

Authors:  D C Montefiori; W E Robinson; W M Mitchell
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

7.  B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus.

Authors:  R D Schrier; J W Gnann; A J Langlois; K Shriver; J A Nelson; M B Oldstone
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

8.  Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex.

Authors:  D J Benos; B H Hahn; J K Bubien; S K Ghosh; N A Mashburn; M A Chaikin; G M Shaw; E N Benveniste
Journal:  Proc Natl Acad Sci U S A       Date:  1994-01-18       Impact factor: 11.205

9.  Oligomerization of the hydrophobic heptad repeat of gp41.

Authors:  H B Bernstein; S P Tucker; S R Kar; S A McPherson; D T McPherson; J W Dubay; J Lebowitz; R W Compans; E Hunter
Journal:  J Virol       Date:  1995-05       Impact factor: 5.103

10.  Impact of Protein Glycosylation on the Design of Viral Vaccines.

Authors:  Kathleen Schön; Bernd Lepenies; Guillaume Goyette-Desjardins
Journal:  Adv Biochem Eng Biotechnol       Date:  2021       Impact factor: 2.635
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