Literature DB >> 19684109

Variations in Hedgehog signaling: divergence and perpetuation in Sufu regulation of Gli.

Laurent Ruel1, Pascal P Thérond.   

Abstract

The Hedgehog (Hh) proteins play a universal role in metazoan development. Nevertheless, fundamental differences exist between Drosophila and vertebrates in the transduction of the Hh signal, notably regarding the role of primary cilia in mammalian cells. In this issue of Genes & Development, Chen and colleagues (pp. 1910-1928) demonstrate that mouse Suppressor of fused (Sufu) regulates the stability of the transcription factors Gli2 and Gli3 by antagonizing the conserved Gli degradation device mediated by Hib/Spop in a cilia-independent manner.

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Year:  2009        PMID： 19684109      PMCID： PMC2725945          DOI： 10.1101/gad.1838109

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  36 in total

1.  Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.

Authors:  G Wang; K Amanai; B Wang; J Jiang
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

2.  Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved.

Authors:  Miao-Hsueh Chen; Christopher W Wilson; Ya-Jun Li; Kelvin King Lo Law; Chi-Sheng Lu; Rhodora Gacayan; Xiaoyun Zhang; Chi-chung Hui; Pao-Tien Chuang
Journal:  Genes Dev       Date:  2009-08-15       Impact factor: 11.361

3.  Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1.

Authors:  P Kogerman; T Grimm; L Kogerman; D Krause; A B Undén; B Sandstedt; R Toftgård; P G Zaphiropoulos
Journal:  Nat Cell Biol       Date:  1999-09       Impact factor: 28.824

4.  Suppressor of Fused represses Gli-mediated transcription by recruiting the SAP18-mSin3 corepressor complex.

Authors:  Steven Yan Cheng; J Michael Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

5.  Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2.

Authors:  Lawrence Lum; Chi Zhang; Sekyung Oh; Randall K Mann; Doris P von Kessler; Jussi Taipale; Frances Weis-Garcia; Ruoyu Gong; Baolin Wang; Philip A Beachy
Journal:  Mol Cell       Date:  2003-11       Impact factor: 17.970

6.  Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster.

Authors:  T Préat
Journal:  Genetics       Date:  1992-11       Impact factor: 4.562

7.  Mutations affecting segment number and polarity in Drosophila.

Authors:  C Nüsslein-Volhard; E Wieschaus
Journal:  Nature       Date:  1980-10-30       Impact factor: 49.962

8.  Patched acts catalytically to suppress the activity of Smoothened.

Authors:  J Taipale; M K Cooper; T Maiti; P A Beachy
Journal:  Nature       Date:  2002-08-22       Impact factor: 49.962

9.  Stability and association of Smoothened, Costal2 and Fused with Cubitus interruptus are regulated by Hedgehog.

Authors:  Laurent Ruel; Ralph Rodriguez; Armel Gallet; Laurence Lavenant-Staccini; Pascal P Thérond
Journal:  Nat Cell Biol       Date:  2003-10-01       Impact factor: 28.824

10.  Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

Authors:  N Méthot; K Basler
Journal:  Development       Date:  2000-09       Impact factor: 6.868
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  9 in total

1.  Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina.

Authors:  Matt A Cwinn; Chantal Mazerolle; Brian McNeill; Randy Ringuette; Sherry Thurig; Chi-chung Hui; Valerie A Wallace
Journal:  J Neurosci       Date:  2011-03-30       Impact factor: 6.167

2.  Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation.

Authors:  Steven A Marks; Daniel Kalderon
Journal:  Development       Date:  2011-06       Impact factor: 6.868

Review 3.  Molecular mechanisms of suppressor of fused in regulating the hedgehog signalling pathway.

Authors:  Dengliang Huang; Yiting Wang; Jiabin Tang; Shiwen Luo
Journal:  Oncol Lett       Date:  2018-03-01       Impact factor: 2.967

4.  Loss of SUFU function in familial multiple meningioma.

Authors:  Mervi Aavikko; Song-Ping Li; Silva Saarinen; Pia Alhopuro; Eevi Kaasinen; Ekaterina Morgunova; Yilong Li; Kari Vesanen; Miriam J Smith; D Gareth R Evans; Minna Pöyhönen; Anne Kiuru; Anssi Auvinen; Lauri A Aaltonen; Jussi Taipale; Pia Vahteristo
Journal:  Am J Hum Genet       Date:  2012-09-07       Impact factor: 11.025

5.  Suppressor of Fused Is Required for Determining Digit Number and Identity via Gli3/Fgfs/Gremlin.

Authors:  Jianying Li; Qihui Wang; Ying Cui; Xueqin Yang; Yan Li; Xiaoyun Zhang; Mengsheng Qiu; Ze Zhang; Zunyi Zhang
Journal:  PLoS One       Date:  2015-05-22       Impact factor: 3.240

Review 6.  Primary Ciliary Signaling in the Skin-Contribution to Wound Healing and Scarring.

Authors:  Mayu Hosio; Viljar Jaks; Heli Lagus; Jyrki Vuola; Rei Ogawa; Esko Kankuri
Journal:  Front Cell Dev Biol       Date:  2020-11-13

7.  Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disc Formation and Maintenance.

Authors:  Diviya Rajesh; Chitra Lekha Dahia
Journal:  Curr Mol Biol Rep       Date:  2018-10-24

8.  A novel PEGylated liposome-encapsulated SANT75 suppresses tumor growth through inhibiting hedgehog signaling pathway.

Authors:  Yike Yuan; Yuwei Zhao; Shengchang Xin; Ni Wu; Jiaolin Wen; Song Li; Lijuan Chen; Yuquan Wei; Hanshuo Yang; Shuo Lin
Journal:  PLoS One       Date:  2013-04-01       Impact factor: 3.240

Review 9.  Hedgehog signalling in the tumourigenesis and metastasis of osteosarcoma, and its potential value in the clinical therapy of osteosarcoma.

Authors:  Zhihong Yao; Lei Han; Yongbin Chen; Fei He; Bin Sun; Santosh Kamar; Ya Zhang; Yihao Yang; Cao Wang; Zuozhang Yang
Journal:  Cell Death Dis       Date:  2018-06-13       Impact factor: 8.469
  9 in total

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