Diviya Rajesh1, Chitra Lekha Dahia2,1. 1. Orthopaedic Soft Tissue Research Program, Hospital for Special Surgery, New York, NY, 10021, USA. 2. Department of Cell and Developmental Biology, Weill Cornell Medicine, Graduate School of Medical Sciences, New York, NY, 10065, USA.
Abstract
A PURPOSE OF REVIEW: The intervertebral discs (IVD) are an essential component of the spine. Degeneration of the discs, commonly due to age or injury, is a leading cause of chronic lower back pain. Despite its high prevalence, there is no effective treatment for disc disease due to limited understanding of disc at the cellular and molecular level. B RECENT FINDINGS: Recent research has demonstrated the importance of the intracellular developmental pathway sonic hedgehog (Shh) during the formation and postnatal maintenance of the IVD. Recent studies corroborate that the down-regulation of SHH expression is associated with pathological changes in the IVDs and demonstrate the reactivation of the hedgehog pathway as a promising avenue for rescuing health disc structure and function. C SUMMARY: Understanding the role of developmental signaling pathways that regulate disc formation and maintenance may help develop strategies to recapitulate the same mechanism for disc treatment and hence improve the quality and longevity of patient lives.
A PURPOSE OF REVIEW: The intervertebral discs (IVD) are an essential component of the spine. Degeneration of the discs, commonly due to age or injury, is a leading cause of chronic lower back pain. Despite its high prevalence, there is no effective treatment for disc disease due to limited understanding of disc at the cellular and molecular level. B RECENT FINDINGS: Recent research has demonstrated the importance of the intracellular developmental pathway sonic hedgehog (Shh) during the formation and postnatal maintenance of the IVD. Recent studies corroborate that the down-regulation of SHH expression is associated with pathological changes in the IVDs and demonstrate the reactivation of the hedgehog pathway as a promising avenue for rescuing health disc structure and function. C SUMMARY: Understanding the role of developmental signaling pathways that regulate disc formation and maintenance may help develop strategies to recapitulate the same mechanism for disc treatment and hence improve the quality and longevity of patient lives.
Authors: Norbert Boos; Sabine Weissbach; Helmut Rohrbach; Christoph Weiler; Kevin F Spratt; Andreas G Nerlich Journal: Spine (Phila Pa 1976) Date: 2002-12-01 Impact factor: 3.468
Authors: P Kogerman; T Grimm; L Kogerman; D Krause; A B Undén; B Sandstedt; R Toftgård; P G Zaphiropoulos Journal: Nat Cell Biol Date: 1999-09 Impact factor: 28.824
Authors: Tamara Caspary; María Jesús García-García; Danwei Huangfu; Jonathan T Eggenschwiler; Michael R Wyler; Andrew S Rakeman; Heather L Alcorn; Kathryn V Anderson Journal: Curr Biol Date: 2002-09-17 Impact factor: 10.834
Authors: Vivian Tam; Peikai Chen; Anita Yee; Nestor Solis; Theo Klein; Mateusz Kudelko; Rakesh Sharma; Wilson Cw Chan; Christopher M Overall; Lisbet Haglund; Pak C Sham; Kathryn Song Eng Cheah; Danny Chan Journal: Elife Date: 2020-12-31 Impact factor: 8.140
Authors: Marcos N Barcellona; Julie E Speer; Liufang Jing; Deepanjali S Patil; Munish C Gupta; Jacob M Buchowski; Lori A Setton Journal: Acta Biomater Date: 2021-07-04 Impact factor: 10.633
Authors: Elizabeth A Terhune; Melissa T Cuevas; Anna M Monley; Cambria I Wethey; Xiaomi Chen; Maria V Cattell; Melisa N Bayrak; Morgan R Bland; Brittan Sutphin; George Devon Trahan; Matthew R G Taylor; Lee A Niswander; Kenneth L Jones; Erin E Baschal; Lilian Antunes; Matthew Dobbs; Christina Gurnett; Bruce Appel; Ryan Gray; Nancy Hadley Miller Journal: Hum Mutat Date: 2021-02-07 Impact factor: 4.878
Authors: Frances C Bach; Kim M de Rooij; Frank M Riemers; Joseph W Snuggs; Willem A M de Jong; Ying Zhang; Laura B Creemers; Danny Chan; Christine Le Maitre; Marianna A Tryfonidou Journal: JOR Spine Date: 2019-11-19