Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.

Literature DB >> 19683921

Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.

Li Cai¹, Wanyi Guan, Wenjun Wang, Wei Zhao, Motomitsu Kitaoka, Jie Shen, Crystal O'Neil, Peng George Wang.

Abstract

We report herein a bacterial N-acetylhexosamine kinase, NahK, with broad substrate specificity towards structurally modified GalNAc analogues, and the production of a GalNAc-1-phosphate library using this kinase.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19683921 DOI： 10.1016/j.bmcl.2009.07.104

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

12 in total

1. Highly efficient synthesis of UDP-GalNAc/GlcNAc analogues with promiscuous recombinant human UDP-GalNAc pyrophosphorylase AGX1.

Authors: Wanyi Guan; Li Cai; Peng George Wang
Journal: Chemistry Date: 2010-12-03 Impact factor: 5.236

2. Comparing substrate specificity of two UDP-sugar pyrophosphorylases and efficient one-pot enzymatic synthesis of UDP-GlcA and UDP-GalA.

Authors: Yuxi Guo; Junqiang Fang; Tiehai Li; Xu Li; Cheng Ma; Xuan Wang; Peng G Wang; Lei Li
Journal: Carbohydr Res Date: 2015-04-16 Impact factor: 2.104

3. Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives.

Authors: Lei Li; Yonghui Liu; Yue Wan; Yanhong Li; Xi Chen; Wei Zhao; Peng George Wang
Journal: Org Lett Date: 2013-10-11 Impact factor: 6.005

4. Chemoenzymatic synthesis of uridine 5'-diphospho-2-acetonyl-2-deoxy-alpha-D-glucose as C(2)-carbon isostere of UDP-GlcNAc.

Authors: Li Cai; Wanyi Guan; Wenlan Chen; Peng George Wang
Journal: J Org Chem Date: 2010-05-21 Impact factor: 4.354

Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.

1. Highly efficient synthesis of UDP-GalNAc/GlcNAc analogues with promiscuous recombinant human UDP-GalNAc pyrophosphorylase AGX1.

2. Comparing substrate specificity of two UDP-sugar pyrophosphorylases and efficient one-pot enzymatic synthesis of UDP-GlcA and UDP-GalA.

3. Efficient enzymatic synthesis of guanosine 5'-diphosphate-sugars and derivatives.

4. Chemoenzymatic synthesis of uridine 5'-diphospho-2-acetonyl-2-deoxy-alpha-D-glucose as C(2)-carbon isostere of UDP-GlcNAc.

5. Chemoenzymatic synthesis of ADP-d-glycero-β-d-manno-heptose and study of the substrate specificity of HldE.

6. Enzymatic synthesis and properties of uridine-5'-O-(2-thiodiphospho)-N-acetylglucosamine.

7. Enzymatic route to preparative-scale synthesis of UDP-GlcNAc/GalNAc, their analogues and GDP-fucose.

8. General Tolerance of Galactosyltransferases toward UDP-galactosamine Expands Their Synthetic Capability.

Review 9. Bifidobacterial enzymes involved in the metabolism of human milk oligosaccharides.

10. Substrate promiscuity of N-acetylhexosamine 1-kinases.