| Literature DB >> 19683077 |
Francieli de Sousa Rabelo1, Licia Maria Henrique da Mota, Rodrigo Aires Corrêa Lima, Francisco Aires Corrêa Lima, Gustavo Barcelos Barra, Jozélio Freire de Carvalho, Angélica Amorim Amato.
Abstract
The Wnt signaling pathways play a key role in cell renewal, and there are two such pathways. In patients with rheumatoid arthritis (RA), the synovial membrane expresses genes such as Wnt and Fz at higher levels than those observed in patients without RA. The Wnt proteins are glycoproteins that bind to receptors of the Fz family on the cell surface. The Wnt/Fz complex controls tissue formation during embryogenesis, as well as throughout the process of limb development and joint formation. Recent studies have suggested that this signaling pathway plays a role in the pathophysiology of RA. Greater knowledge of the role of the Wnt signaling pathway in RA could improve understanding of the differences in RA clinical presentation and prognosis. Further studies should also focus on Wnt family members as molecular targets in the treatment of RA. Copyright 2009 Elsevier B.V. All rights reserved.Entities:
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Year: 2009 PMID： 19683077 DOI： 10.1016/j.autrev.2009.08.003
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754