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Literature DB >> 19680249

The type III secretion system of Pseudomonas aeruginosa: infection by injection.

Abstract

The Gram-negative bacterium Pseudomonas aeruginosa uses a complex type III secretion apparatus to inject effector proteins into host cells. The configuration of this secretion machinery, the activities of the proteins that are injected by it and the consequences of this process for infection are now being elucidated. This Review summarizes our current knowledge of P. aeruginosa type III secretion, including the secretion and translocation machinery, the regulation of this machinery, and the associated chaperones and effector proteins. The features of this interesting secretion system have important implications for the pathogenesis of P. aeruginosa infections and for other type III secretion systems.

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Year: 2009 PMID： 19680249 PMCID： PMC2766515 DOI： 10.1038/nrmicro2199

Source DB: PubMed Journal: Nat Rev Microbiol ISSN： 1740-1526 Impact factor: 60.633

172 in total

1. ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G.

Authors: M J Riese; A Wittinghofer; J T Barbieri
Journal: Biochemistry Date: 2001-03-20 Impact factor: 3.162

2. Type III secretion/intoxication system important in virulence of Pseudomonas aeruginosa infections in burns.

Authors: I A Holder; A N Neely; D W Frank
Journal: Burns Date: 2001-03 Impact factor: 2.744

3. Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.

Authors: C E Stebbins; J E Galán
Journal: Mol Cell Date: 2000-12 Impact factor: 17.970

4. Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU.

Authors: V Finck-Barbançon; D W Frank
Journal: J Bacteriol Date: 2001-07 Impact factor: 3.490

5. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections.

Authors: A Roy-Burman; R H Savel; S Racine; B L Swanson; N S Revadigar; J Fujimoto; T Sawa; D W Frank; J P Wiener-Kronish
Journal: J Infect Dis Date: 2001-05-17 Impact factor: 5.226

6. Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.

Authors: T K Geiser; B I Kazmierczak; L K Garrity-Ryan; M A Matthay; J N Engel
Journal: Cell Microbiol Date: 2001-04 Impact factor: 3.715

7. Pore-forming activity of type III system-secreted proteins leads to oncosis of Pseudomonas aeruginosa-infected macrophages.

Authors: D Dacheux; J Goure; J Chabert; Y Usson; I Attree
Journal: Mol Microbiol Date: 2001-04 Impact factor: 3.501

8. Comparison of the exoS gene and protein expression in soil and clinical isolates of Pseudomonas aeruginosa.

Authors: M W Ferguson; J A Maxwell; T S Vincent; J da Silva; J C Olson
Journal: Infect Immun Date: 2001-04 Impact factor: 3.441

9. Structure of the ExoS GTPase activating domain.

Authors: M Würtele; L Renault; J T Barbieri; A Wittinghofer; E Wolf
Journal: FEBS Lett Date: 2001-02-23 Impact factor: 4.124

10. Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells.

Authors: E Hoiczyk; G Blobel
Journal: Proc Natl Acad Sci U S A Date: 2001-04-03 Impact factor: 11.205

348 in total

1. The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties.

Authors: Evan D Brutinel; Jessica M King; Anne E Marsden; Timothy L Yahr
Journal: J Bacteriol Date: 2012-03-09 Impact factor: 3.490

2. Orientation of Pseudomonas aeruginosa ExsA monomers bound to promoter DNA and base-specific contacts with the P(exoT) promoter.

Authors: Jessica M King; Evan D Brutinel; Anne E Marsden; Florian D Schubot; Timothy L Yahr
Journal: J Bacteriol Date: 2012-03-09 Impact factor: 3.490

The type III secretion system of Pseudomonas aeruginosa: infection by injection.

1. ADP ribosylation of Arg41 of Rap by ExoS inhibits the ability of Rap to interact with its guanine nucleotide exchange factor, C3G.

2. Type III secretion/intoxication system important in virulence of Pseudomonas aeruginosa infections in burns.

3. Modulation of host signaling by a bacterial mimic: structure of the Salmonella effector SptP bound to Rac1.

4. Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU.

5. Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections.

6. Pseudomonas aeruginosa ExoT inhibits in vitro lung epithelial wound repair.

7. Pore-forming activity of type III system-secreted proteins leads to oncosis of Pseudomonas aeruginosa-infected macrophages.

8. Comparison of the exoS gene and protein expression in soil and clinical isolates of Pseudomonas aeruginosa.

9. Structure of the ExoS GTPase activating domain.

10. Polymerization of a single protein of the pathogen Yersinia enterocolitica into needles punctures eukaryotic cells.

1. The distal ExsA-binding site in Pseudomonas aeruginosa type III secretion system promoters is the primary determinant for promoter-specific properties.

2. Orientation of Pseudomonas aeruginosa ExsA monomers bound to promoter DNA and base-specific contacts with the P(exoT) promoter.

3. Structure of the basal components of a bacterial transporter.

4. Functional characterization of a phospholipase A(2) homolog from Rickettsia typhi.

5. Role of the membrane localization domain of the Pseudomonas aeruginosa effector protein ExoU in cytotoxicity.

Review 6. Innate immune responses to Pseudomonas aeruginosa infection.

7. Evolutionary genomics of epidemic and nonepidemic strains of Pseudomonas aeruginosa.

8. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection.

9. Prevention of ESKAPE pathogen biofilm formation by antimicrobial peptides WLBU2 and LL37.

10. Pseudomonas aeruginosa uses T3SS to inhibit diabetic wound healing.