Marc P McRae1. 1. National University of Health Sciences, Department of Physiology and Biochemistry, Lombard, IL.
Abstract
OBJECTIVE: Hypertension is a common condition with high mortality from associated diseases. Epidemiological evidence suggests that a dietary deficiency of vitamin C may be a risk factor for hypertension. However the literature on vitamin C interventional trials appears divided on the efficacy of vitamin C utilization clinically. METHODS: A literature search and review of published trials using vitamin C in treating patients with hypertension was undertaken. Relevant references were located using MEDLINE (1966-2005) and the bibliographies of located articles. RESULTS: Thirteen trials making up 14 separate groups were identified and analyzed providing a pooled population of 284 hypertensive patients (52% female), with a weighted mean age of 58.8 +/- 9.5 years. Median vitamin C dose and study intervention duration was 500mg/day and 6 weeks respectively. The weighted mean baseline and post treatment systolic blood pressures across all 14 groups were 149.6 +/- 11.1 and 145.7 +/- 11.0 mmHg respectively. This represented a systolic blood pressure decrease of 3.9 mmHg. Seven of the 14 groups ascertained statistically significant reductions (p < .05) in systolic blood pressures. However only 2 of the 14 groups found significant reductions in diastolic blood pressure. The weighted mean baseline and post treatment diastolic blood pressures across all 14 groups were 84.6 +/- 4.4 and 82.5 +/- 4.1 mmHg respectively. This represented a diastolic blood pressure decrease of 2.1 mmHg. CONCLUSION: Vitamin C supplementation in hypertensive patients appears to possess modest effects on reducing systolic blood and diastolic blood pressure.
OBJECTIVE:Hypertension is a common condition with high mortality from associated diseases. Epidemiological evidence suggests that a dietary deficiency of vitamin C may be a risk factor for hypertension. However the literature on vitamin C interventional trials appears divided on the efficacy of vitamin C utilization clinically. METHODS: A literature search and review of published trials using vitamin C in treating patients with hypertension was undertaken. Relevant references were located using MEDLINE (1966-2005) and the bibliographies of located articles. RESULTS: Thirteen trials making up 14 separate groups were identified and analyzed providing a pooled population of 284 hypertensivepatients (52% female), with a weighted mean age of 58.8 +/- 9.5 years. Median vitamin C dose and study intervention duration was 500mg/day and 6 weeks respectively. The weighted mean baseline and post treatment systolic blood pressures across all 14 groups were 149.6 +/- 11.1 and 145.7 +/- 11.0 mmHg respectively. This represented a systolic blood pressure decrease of 3.9 mmHg. Seven of the 14 groups ascertained statistically significant reductions (p < .05) in systolic blood pressures. However only 2 of the 14 groups found significant reductions in diastolic blood pressure. The weighted mean baseline and post treatment diastolic blood pressures across all 14 groups were 84.6 +/- 4.4 and 82.5 +/- 4.1 mmHg respectively. This represented a diastolic blood pressure decrease of 2.1 mmHg. CONCLUSION:Vitamin C supplementation in hypertensivepatients appears to possess modest effects on reducing systolic blood and diastolic blood pressure.
Authors: N Gokce; J F Keaney; B Frei; M Holbrook; M Olesiak; B J Zachariah; C Leeuwenburgh; J W Heinecke; J A Vita Journal: Circulation Date: 1999-06-29 Impact factor: 29.690