| Literature DB >> 19670359 |
Stoyan Tanev1, Wenbo Sun, James Pond, Valery V Tuchin, Vladimir P Zharov.
Abstract
The formulation of the finite-difference time-domain (FDTD) approach is presented in the framework of its potential applications to in-vivo flow cytometry based on light scattering. The consideration is focused on comparison of light scattering by a single biological cell alone in controlled refractive-index matching conditions and by cells labeled by gold nanoparticles. The optical schematics including phase contrast (OPCM) microscopy as a prospective modality for in-vivo flow cytometry is also analyzed. The validation of the FDTD approach for the simulation of flow cytometry may open up a new avenue in the development of advanced cytometric techniques based on scattering effects from nanoscale targets. 2009 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimEntities:
Mesh:
Substances:
Year: 2009 PMID: 19670359 PMCID: PMC2893151 DOI: 10.1002/jbio.200910039
Source DB: PubMed Journal: J Biophotonics ISSN: 1864-063X Impact factor: 3.207