Literature DB >> 19669306

Advanced hepatic fibrosis and cirrhosis due to nonalcoholic fatty liver disease in Sri Lankan children: a preliminary report.

S Rajindrajith1, A S Dassanayake, J Hewavisenthi, H J de Silva.   

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases and may progress to advanced hepatic fibrosis and cirrhosis in some patients. Cirrhosis due to NAFLD is considered extremely rare in children in the Asia-Pacific region. We report the characteristics of 5 children with advanced hepatic fibrosis and cirrhosis due to NAFLD. Four of them were obese, and all of them had high alanine transaminase levels and ultrasonographic evidence of fatty liver. None had diabetes mellitus or hyperlipidemia. The calculated HOMA-IR was more than two in all five cases. Liver biopsy showed stage III fibrosis in 2 patients and stage IV fibrosis (cirrhosis) in 3.

Entities:  

Year:  2008        PMID： 19669306      PMCID： PMC2716850          DOI： 10.1007/s12072-008-9062-5

Source DB:  PubMed          Journal:  Hepatol Int        ISSN： 1936-0533            Impact factor:   6.047


  13 in total

1.  Histopathology of pediatric nonalcoholic fatty liver disease.

Authors:  Jeffrey B Schwimmer; Cynthia Behling; Robert Newbury; Reena Deutsch; Caroline Nievergelt; Nicholas J Schork; Joel E Lavine
Journal:  Hepatology       Date:  2005-09       Impact factor: 17.425

2.  Non-alcoholic steatohepatitis in children and adolescents.

Authors:  N D Manton; J Lipsett; D J Moore; G P Davidson; A J Bourne; R T Couper
Journal:  Med J Aust       Date:  2000-11-06       Impact factor: 7.738

3.  Idiopathic steatohepatitis in childhood: a multicenter retrospective study.

Authors:  A D Baldridge; A R Perez-Atayde; F Graeme-Cook; L Higgins; J E Lavine
Journal:  J Pediatr       Date:  1995-11       Impact factor: 4.406

4.  Steatohepatitis in obese children: a cause of chronic liver dysfunction.

Authors:  J R Moran; F K Ghishan; S A Halter; H L Greene
Journal:  Am J Gastroenterol       Date:  1983-06       Impact factor: 10.864

5.  Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease.

Authors:  Jeffrey B Schwimmer; Reena Deutsch; Jeffrey B Rauch; Cynthia Behling; Robert Newbury; Joel E Lavine
Journal:  J Pediatr       Date:  2003-10       Impact factor: 4.406

6.  Fatty liver and its fibrous changes found in simple obesity of children.

Authors:  A Kinugasa; K Tsunamoto; N Furukawa; T Sawada; T Kusunoki; N Shimada
Journal:  J Pediatr Gastroenterol Nutr       Date:  1984-06       Impact factor: 2.839

Review 7.  Non-alcoholic steatohepatitis: what is it, and why is it important in the Asia-Pacific region?

Authors:  Geoffrey C Farrell
Journal:  J Gastroenterol Hepatol       Date:  2003-02       Impact factor: 4.029

8.  Obese children with steatohepatitis can develop cirrhosis in childhood.

Authors:  Jean P Molleston; Frances White; Jeffrey Teckman; Joseph F Fitzgerald
Journal:  Am J Gastroenterol       Date:  2002-09       Impact factor: 10.864

9.  Nonalcoholic fatty liver disease: assessment of variability in pathologic interpretations.

Authors:  Z M Younossi; T Gramlich; Y C Liu; C Matteoni; M Petrelli; J Goldblum; L Rybicki; A J McCullough
Journal:  Mod Pathol       Date:  1998-06       Impact factor: 7.842

Review 10.  Fatty liver disease in children.

Authors:  A W Marion; A J Baker; A Dhawan
Journal:  Arch Dis Child       Date:  2004-07       Impact factor: 3.791
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  2 in total

1.  Non-alcoholic fatty liver disease and its associations among adolescents in an urban, Sri Lankan community.

Authors:  Shaman Rajindrajith; Arunasalam Pathmeswaran; Chamilka Jayasinghe; Dulani Kottahachchi; Anuradhani Kasturiratne; Shamila T de Silva; Madunil A Niriella; Anuradha S Dassanayake; Arjuna P de Silva; H Janaka de Silva
Journal:  BMC Gastroenterol       Date:  2017-11-29       Impact factor: 3.067

Review 2.  Nonalcoholic Fatty Liver Disease: Identifying the Disease Burden in Sri Lanka.

Authors:  Anuradha S Dassanayake
Journal:  Euroasian J Hepatogastroenterol       Date:  2018-05-01
  2 in total

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