Literature DB >> 19666223

Addressing the malaria drug resistance challenge using flow cytometry to discover new antimalarials.

Brian T Grimberg1, Maria M Jaworska, Lindsay B Hough, Peter A Zimmerman, James G Phillips.   

Abstract

A new flow cytometry method that uses an optimized DNA and RNA staining strategy to monitor the growth and development of the Plasmodium falciparum strain W2mef has been used in a pilot study and has identified Bay 43-9006 1, SU 11274 2, and TMC 125 5 as compounds that exhibit potent (<1 microM) overall and ring stage in vitro antimalarial activity.

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Year:  2009        PMID： 19666223      PMCID： PMC3131497          DOI： 10.1016/j.bmcl.2009.07.095

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  39 in total

1.  Histidine-rich protein II: a novel approach to malaria drug sensitivity testing.

Authors:  Harald Noedl; Walther H Wernsdorfer; Robert Scott Miller; Chansuda Wongsrichanalai
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

2.  Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity.

Authors:  H Ali; G M König; S A Khalid; A D Wright; R Kaminsky
Journal:  J Ethnopharmacol       Date:  2002-12       Impact factor: 4.360

3.  A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.

Authors:  P J Rosenthal; J H McKerrow; M Aikawa; H Nagasawa; J H Leech
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

Review 4.  Antimalarial drug resistance.

Authors:  Nicholas J White
Journal:  J Clin Invest       Date:  2004-04       Impact factor: 14.808

5.  The Met kinase inhibitor SU11274 exhibits a selective inhibition pattern toward different receptor mutated variants.

Authors:  Sylvie Berthou; Daniel M Aebersold; Laura S Schmidt; Deborah Stroka; Christine Heigl; Bruno Streit; Denise Stalder; Guenther Gruber; Congxin Liang; Anthony R Howlett; Daniel Candinas; Richard H Greiner; Kenneth E Lipson; Yitzhak Zimmer
Journal:  Oncogene       Date:  2004-07-08       Impact factor: 9.867

6.  Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.

Authors:  Angus Cameron; Jon Read; Rebecca Tranter; Victoria J Winter; Richard B Sessions; R Leo Brady; Livia Vivas; Anna Easton; Howard Kendrick; Simon L Croft; David Barros; Jose Luis Lavandera; José Julio Martin; Felix Risco; Silvestre García-Ochoa; Fracisco Javier Gamo; Laura Sanz; Luisa Leon; Jose R Ruiz; Raquel Gabarró; Araceli Mallo; Federico Gómez de las Heras
Journal:  J Biol Chem       Date:  2004-04-26       Impact factor: 5.157

7.  Stage-dependent effects of chloroquine on Plasmodium falciparum in vitro.

Authors:  A Yayon; J A Vande Waa; M Yayon; T G Geary; J B Jensen
Journal:  J Protozool       Date:  1983-11

8.  Tetraethylthiuram disulfide (Antabuse) inhibits the human malaria parasite Plasmodium falciparum.

Authors:  L W Scheibel; A Adler; W Trager
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique.

Authors:  R E Desjardins; C J Canfield; J D Haynes; J D Chulay
Journal:  Antimicrob Agents Chemother       Date:  1979-12       Impact factor: 5.191

10.  BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.

Authors:  Scott M Wilhelm; Christopher Carter; Liya Tang; Dean Wilkie; Angela McNabola; Hong Rong; Charles Chen; Xiaomei Zhang; Patrick Vincent; Mark McHugh; Yichen Cao; Jaleel Shujath; Susan Gawlak; Deepa Eveleigh; Bruce Rowley; Li Liu; Lila Adnane; Mark Lynch; Daniel Auclair; Ian Taylor; Rich Gedrich; Andrei Voznesensky; Bernd Riedl; Leonard E Post; Gideon Bollag; Pamela A Trail
Journal:  Cancer Res       Date:  2004-10-01       Impact factor: 13.312
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  11 in total

1.  Myristicyclins A and B: antimalarial procyanidins from Horsfieldia spicata from Papua New Guinea.

Authors:  Zhenyu Lu; Ryan M Van Wagoner; Cristopher D Pond; Ann R Pole; James B Jensen; D'Arbra Blankenship; Brian T Grimberg; Robert Kiapranis; Teatulohi K Matainaho; Louis R Barrows; Chris M Ireland
Journal:  Org Lett       Date:  2013-12-19       Impact factor: 6.005

Review 2.  Methodology and application of flow cytometry for investigation of human malaria parasites.

Authors:  Brian T Grimberg
Journal:  J Immunol Methods       Date:  2011-02-04       Impact factor: 2.303

3.  3-bromohomofascaplysin A, a fascaplysin analogue from a Fijian Didemnum sp. ascidian.

Authors:  Zhenyu Lu; Yuanqing Ding; Xing-Cong Li; Daignon R Djigbenou; Brian T Grimberg; Daneel Ferreira; Chris M Ireland; Ryan M Van Wagoner
Journal:  Bioorg Med Chem       Date:  2011-06-01       Impact factor: 3.641

4.  Expanding the Antimalarial Drug Arsenal-Now, But How?

Authors:  Brian T Grimberg; Rajeev K Mehlotra
Journal:  Pharmaceuticals (Basel)       Date:  2011-05-01

5.  Simple flow cytometric detection of haemozoin containing leukocytes and erythrocytes for research on diagnosis, immunology and drug sensitivity testing.

Authors:  Rosangela Frita; Maria Rebelo; Ana Pamplona; Ana M Vigario; Maria M Mota; Martin P Grobusch; Thomas Hänscheid
Journal:  Malar J       Date:  2011-03-31       Impact factor: 2.979

6.  An adaptable two-color flow cytometric assay to quantitate the invasion of erythrocytes by Plasmodium falciparum parasites.

Authors:  Michel Theron; Richard L Hesketh; Sathish Subramanian; Julian C Rayner
Journal:  Cytometry A       Date:  2010-11       Impact factor: 4.355

7.  Antimalarial Activity of Acetylenic Thiophenes from Echinops hoehnelii Schweinf.

Authors:  Helen Bitew; Wendimagegn Mammo; Ariaya Hymete; Mariamawit Yonathan Yeshak
Journal:  Molecules       Date:  2017-11-21       Impact factor: 4.411

8.  A comparative study of a flow-cytometry-based assessment of in vitro Plasmodium falciparum drug sensitivity.

Authors:  Stephan Karl; Rina Pm Wong; Tim G St Pierre; Timothy Me Davis
Journal:  Malar J       Date:  2009-12-14       Impact factor: 2.979

9.  Synthesis of 2,1-benzisoxazole-3(1H)-ones by base-mediated photochemical N-O bond-forming cyclization of 2-azidobenzoic acids.

Authors:  Daria Yu Dzhons; Andrei V Budruev
Journal:  Beilstein J Org Chem       Date:  2016-05-04       Impact factor: 2.883

10.  Growth of Plasmodium falciparum in response to a rotating magnetic field.

Authors:  Rebecca C Gilson; Robert J Deissler; Richard F Bihary; William C Condit; Mary E Thompson; D'Arbra Blankenship; Kerry O Grimberg; Robert W Brown; Brian T Grimberg
Journal:  Malar J       Date:  2018-05-03       Impact factor: 2.979
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