| Literature DB >> 19665962 |
Abstract
A new study by Shimono et al. (2009) demonstrates that certain microRNAs that regulate the self-renewal factor BMI1 are downregulated in purified populations of normal mammary epithelial stem cells and breast tumor-initiating cells. These findings have important implications for the regulation of self-renewal and differentiation by microRNAs and suggest new ways of targeting cancer stem cells.Entities:
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Year: 2009 PMID： 19665962 DOI： 10.1016/j.cell.2009.07.025
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582