| Literature DB >> 19665390 |
Kinga Nawalany1, Aleksandra Rusin, Mariusz Kepczyński, Alexei Mikhailov, Gabriela Kramer-Marek, Mirosław Snietura, Jan Połtowicz, Zdzisław Krawczyk, Maria Nowakowska.
Abstract
Two photosensitizing systems: (1) tetrakis(4-hydroxyphenyl)porphyrin (p-THPP) encapsulated in sterically stabilized liposomes (SSL) and (2) p-THPP functionalized by covalent attachment of poly(ethylene glycol) (p-THPP-PEG(2000)) were studied in vitro. The dark and photo cytotoxicity of these systems were evaluated on two cell lines: HCT 116, a human colorectal carcinoma cell line, and DU 145, a prostate cancer cell line and compared with these determined for free p-THPP. It was demonstrated that both encapsulation in liposomes as well as attachment of PEG chain result in pronounced reduction of the dark cytotoxicity of the parent porphyrin. The liposomal formulation showed higher than p-THPP-PEG(2000) photocytotoxicity towards both cell lines used in the studies.Entities:
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Year: 2009 PMID： 19665390 DOI： 10.1016/j.jphotobiol.2009.07.005
Source DB: PubMed Journal: J Photochem Photobiol B ISSN： 1011-1344 Impact factor: 6.252