Literature DB >> 19665376

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C.

Daniel Guay1, Christian Beaulieu, Jean-Francois Truchon, T Jagadeeswar Reddy, Robert Zamboni, Christopher I Bayly, Nathalie Methot, Joel Rubin, Diane Ethier, M David Percival.   

Abstract

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.

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Year:  2009        PMID： 19665376     DOI： 10.1016/j.bmcl.2009.07.114

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Discovery of novel cyanamide-based inhibitors of cathepsin C.

Authors:  Dramane Lainé; Michael Palovich; Brent McCleland; Emilie Petitjean; Isabelle Delhom; Haibo Xie; Jianghe Deng; Guoliang Lin; Roderick Davis; Anais Jolit; Neysa Nevins; Baoguang Zhao; Jim Villa; Jessica Schneck; Patrick McDevitt; Robert Midgett; Casey Kmett; Sandra Umbrecht; Brian Peck; Alicia Bacon Davis; David Bettoun
Journal:  ACS Med Chem Lett       Date:  2010-11-10       Impact factor: 4.345

2.  DPP1 Inhibitors: Exploring the Role of Water in the S2 Pocket of DPP1 with Substituted Pyrrolidines.

Authors:  Helena Käck; Kevin Doyle; Samantha J Hughes; Michael S Bodnarchuk; Hans Lönn; Amanda Van De Poël; Nicholas Palmer
Journal:  ACS Med Chem Lett       Date:  2019-07-15       Impact factor: 4.345

3.  Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes.

Authors:  Edgar Deu; Melissa J Leyva; Victoria E Albrow; Mark J Rice; Jonathan A Ellman; Matthew Bogyo
Journal:  Chem Biol       Date:  2010-08-27

4.  Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

Authors:  Yveline Hamon; Monika Legowska; Virginie Hervé; Sandrine Dallet-Choisy; Sylvain Marchand-Adam; Lise Vanderlynden; Michèle Demonte; Rich Williams; Christopher J Scott; Mustapha Si-Tahar; Nathalie Heuzé-Vourc'h; Gilles Lalmanach; Dieter E Jenne; Adam Lesner; Francis Gauthier; Brice Korkmaz
Journal:  J Biol Chem       Date:  2016-02-16       Impact factor: 5.157

5.  Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis.

Authors:  Anne-Sophie Lamort; Yveline Hamon; Cezary Czaplewski; Artur Gieldon; Seda Seren; Laurent Coquet; Fabien Lecaille; Adam Lesner; Gilles Lalmanach; Francis Gauthier; Dieter Jenne; Brice Korkmaz
Journal:  Int J Mol Sci       Date:  2019-09-25       Impact factor: 5.923

6.  Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

Authors:  Laura E de Vries; Mateo I Sanchez; Katarzyna Groborz; Laurie Kuppens; Marcin Poreba; Christine Lehmann; Neysa Nevins; Chrislaine Withers-Martinez; David J Hirst; Fang Yuan; Shirin Arastu-Kapur; Martin Horn; Michael Mares; Matthew Bogyo; Marcin Drag; Edgar Deu
Journal:  FEBS J       Date:  2019-06-24       Impact factor: 5.542

7.  Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening.

Authors:  Mateo I Sanchez; Laura E de Vries; Christine Lehmann; Jeong T Lee; Kenny K Ang; Christopher Wilson; Steven Chen; Michelle R Arkin; Matthew Bogyo; Edgar Deu
Journal:  PLoS One       Date:  2019-12-18       Impact factor: 3.240

Review 8.  Lung Protection by Cathepsin C Inhibition: A New Hope for COVID-19 and ARDS?

Authors:  Brice Korkmaz; Adam Lesner; Sylvain Marchand-Adam; Celia Moss; Dieter E Jenne
Journal:  J Med Chem       Date:  2020-08-07       Impact factor: 7.446
  8 in total

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