Literature DB >> 19663463

Novel and direct transformation of methyl ketones or carbinols to primary amides by employing aqueous ammonia.

Liping Cao1, Jiaoyang Ding, Meng Gao, Zihua Wang, Juan Li, Anxin Wu.   

Abstract

A novel and direct transformation of aryl, heteroaryl, vinyl, or ethynyl methyl ketones or carbinols to corresponding primary amides has been developed. An iodine-NH(3).H(2)O system was proven to be efficient for this reaction and afforded the expected products with good yields in aqueous media. A tandem Lieben-Haller-Bauer reaction mechanism was involved in this type of reaction and is proposed for the first time.

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Year:  2009        PMID： 19663463     DOI： 10.1021/ol901250c

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Highly efficient C(CO)-C(alkyl) bond cleavage in ketones to access esters over ultrathin N-doped carbon nanosheets.

Authors:  Manli Hua; Jinliang Song; Xin Huang; Honglei Fan; Tianbin Wu; Qinglei Meng; Zhanrong Zhang; Buxing Han
Journal:  Chem Sci       Date:  2022-04-11       Impact factor: 9.969

2.  A Versatile Equilibrium Method for the Synthesis of High-Strength, Ladder-like Polyphenylsilsesquioxanes with Finely Tunable Molecular Parameters.

Authors:  Tatyana O Ershova; Anton A Anisimov; Maxim N Temnikov; Maxim A Novikov; Mikhail I Buzin; Galina G Nikiforova; Yulia S Dyuzhikova; Ivan E Ushakov; Olga I Shchegolikhina; Aziz M Muzafarov
Journal:  Polymers (Basel)       Date:  2021-12-18       Impact factor: 4.329

3.  Acceptorless dehydrogenative synthesis of primary amides from alcohols and ammonia.

Authors:  Jie Luo; Quan-Quan Zhou; Michael Montag; Yehoshoa Ben-David; David Milstein
Journal:  Chem Sci       Date:  2022-03-02       Impact factor: 9.825

4.  Vinylogous Nitro-Haloform Reaction Enables Aromatic Amination.

Authors:  Claudio Monasterolo; Mauro F A Adamo
Journal:  Org Lett       Date:  2022-06-28       Impact factor: 6.072

5.  Ca(OH)2-Catalyzed Condensation of Aldehydes with Methyl ketones in Dilute Aqueous Ethanol: A Comprehensive Access to α,β-Unsaturated Ketones.

Authors:  Lei Yu; Mengting Han; Jie Luan; Lin Xu; Yuanhua Ding; Qing Xu
Journal:  Sci Rep       Date:  2016-07-22       Impact factor: 4.379

6.  Copper-Catalyzed Syntheses of Pyrene-Pyrazole Pharmacophores and Structure Activity Studies for Tubulin Polymerization.

Authors:  Dinabandhu Sar; Indrajit Srivastava; Santosh K Misra; Fatemeh Ostadhossein; Parinaz Fathi; Dipanjan Pan
Journal:  ACS Omega       Date:  2018-06-13
  6 in total

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