Literature DB >> 19661417

Looking forward in pharmaceutical process chemistry.

Ian W Davies1, Christopher J Welch.   

Abstract

Core activities of process chemistry involve the synthesis of drug candidates at a scale that supports clinical evaluations and the creation of a manufacturing process that is safe, robust, and cost effective. Innovative problem solving has always been a key element in process chemistry and will be increasingly important for addressing emerging challenges in science, globalization, and commoditization. The acquisition and creation of platform chemical technologies that enable rapid problem solving through the use of high-throughput experimentation will continue to be an important focus going forward. Linking and deploying platforms throughout the discovery-development continuum is expected to enable drug discovery. Increasing collaboration with academia will also become more important for accessing technical solutions and providing the next generation of innovative problem solvers.

Mesh:

Year:  2009        PMID: 19661417     DOI: 10.1126/science.1174501

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  5 in total

1.  Positional Selectivity in C-H Functionalizations of 2-Benzylfurans with Bimetallic Catalysts.

Authors:  Jiadi Zhang; Sheng-Chun Sha; Ana Bellomo; Nisalak Trongsiriwat; Feng Gao; Neil C Tomson; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2016-03-18       Impact factor: 15.419

2.  Reducing Challenges in Organic Synthesis with Stereoselective Hydrogenation and Tandem Catalysis.

Authors:  Patrick D Parker; Xintong Hou; Vy M Dong
Journal:  J Am Chem Soc       Date:  2021-04-23       Impact factor: 16.383

3.  Overcoming the limitations of directed C-H functionalizations of heterocycles.

Authors:  Yue-Jin Liu; Hui Xu; Wei-Jun Kong; Ming Shang; Hui-Xiong Dai; Jin-Quan Yu
Journal:  Nature       Date:  2014-11-10       Impact factor: 49.962

4.  NiXantphos: a deprotonatable ligand for room-temperature palladium-catalyzed cross-couplings of aryl chlorides.

Authors:  Jiadi Zhang; Ana Bellomo; Nisalak Trongsiriwat; Tiezheng Jia; Patrick J Carroll; Spencer D Dreher; Matthew T Tudge; Haolin Yin; Jerome R Robinson; Eric J Schelter; Patrick J Walsh
Journal:  J Am Chem Soc       Date:  2014-04-21       Impact factor: 15.419

5.  Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity.

Authors:  Lu Yang; Thomas Wenzel; R Thomas Williamson; Melodie Christensen; Wes Schafer; Christopher J Welch
Journal:  ACS Cent Sci       Date:  2016-04-20       Impact factor: 14.553

  5 in total

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