| Literature DB >> 19660458 |
Katsumi Iizuka1, Jun Takeda, Yukio Horikawa.
Abstract
Fibroblast growth factor 21 (FGF21) has beneficial effects of improving the plasma glucose and lipid profiles in diabetic rodents. Here, we investigated carbohydrate response element binding protein (ChREBP) involvement in the regulation of FGF21 mRNA expression in liver. Glucose stimulation and adenoviral overexpression of dominant active ChREBP increased FGF21 mRNA. Consistently, adenoviral expression of dominant negative Mlx inhibited glucose induction of FGF21 mRNA. Furthermore, deletion studies of mouse FGF21 gene promoter (-2000 to +65 bp) revealed a glucose responsive region between -74 and -52 bp. These findings suggest that FGF21 expression is regulated by ChREBP.Entities:
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Year: 2009 PMID： 19660458 DOI： 10.1016/j.febslet.2009.07.053
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124