Literature DB >> 26428296

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.

Kathleen R Markan1, Matthew J Potthoff2.   

Abstract

The metabolic fibroblast growth factors (FGFs), FGF1, FGF15/19, and FGF21 differ from classic FGFs in that they modulate energy homeostasis in response to fluctuating nutrient availability. These unique mediators of metabolism regulate a number of physiological processes which contribute to their potent pharmacological properties. Administration of pharmacological doses of these FGFs causes weight loss, increases energy expenditure, and improves carbohydrate and lipid metabolism in obese animal models. However, many questions remain regarding the precise molecular and physiological mechanisms governing the effects of individual metabolic FGFs. Here we review the metabolic actions of FGF1, FGF15/19, and FGF21 while providing insights into their pharmacological effects by examining known biological functions.
Copyright © 2015 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  FGF1; FGF15; FGF19; FGF21; Metabolism; Obesity

Mesh：

Substances：

Year:  2015        PMID： 26428296      PMCID： PMC4814376          DOI： 10.1016/j.semcdb.2015.09.021

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  114 in total

1.  FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.

Authors:  Qingning Liang; Ling Zhong; Jialiang Zhang; Yu Wang; Stefan R Bornstein; Chris R Triggle; Hong Ding; Karen S L Lam; Aimin Xu
Journal:  Diabetes       Date:  2014-07-14       Impact factor: 9.461

2.  Separating mitogenic and metabolic activities of fibroblast growth factor 19 (FGF19).

Authors:  Xinle Wu; Hongfei Ge; Bryan Lemon; Steven Vonderfecht; Helene Baribault; Jennifer Weiszmann; Jamila Gupte; Jonitha Gardner; Richard Lindberg; Zhulun Wang; Yang Li
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-26       Impact factor: 11.205

3.  Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats.

Authors:  David A Sarruf; Joshua P Thaler; Gregory J Morton; Jonathan German; Jonathan D Fischer; Kayoko Ogimoto; Michael W Schwartz
Journal:  Diabetes       Date:  2010-03-31       Impact factor: 9.461

4.  Stromal gene expression predicts clinical outcome in breast cancer.

Authors:  Greg Finak; Nicholas Bertos; Francois Pepin; Svetlana Sadekova; Margarita Souleimanova; Hong Zhao; Haiying Chen; Gulbeyaz Omeroglu; Sarkis Meterissian; Atilla Omeroglu; Michael Hallett; Morag Park
Journal:  Nat Med       Date:  2008-04-27       Impact factor: 53.440

5.  Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice.

Authors:  João Paulo G Camporez; François R Jornayvaz; Max C Petersen; Dominik Pesta; Blas A Guigni; Julie Serr; Dongyan Zhang; Mario Kahn; Varman T Samuel; Michael J Jurczak; Gerald I Shulman
Journal:  Endocrinology       Date:  2013-06-13       Impact factor: 4.736

6.  FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis.

Authors:  Serkan Kir; Sara A Beddow; Varman T Samuel; Paul Miller; Stephen F Previs; Kelly Suino-Powell; H Eric Xu; Gerald I Shulman; Steven A Kliewer; David J Mangelsdorf
Journal:  Science       Date:  2011-03-25       Impact factor: 47.728

7.  Characterization of a FGF19 variant with altered receptor specificity revealed a central role for FGFR1c in the regulation of glucose metabolism.

Authors:  Hongfei Ge; Helene Baribault; Steven Vonderfecht; Bryan Lemon; Jennifer Weiszmann; Jonitha Gardner; Ki Jeong Lee; Jamila Gupte; Paramita Mookherjee; Minghan Wang; Jackie Sheng; Xinle Wu; Yang Li
Journal:  PLoS One       Date:  2012-03-23       Impact factor: 3.240

8.  Differential specificity of endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in complex with KLB.

Authors:  Chaofeng Yang; Chengliu Jin; Xiaokun Li; Fen Wang; Wallace L McKeehan; Yongde Luo
Journal:  PLoS One       Date:  2012-03-19       Impact factor: 3.240

9.  A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.

Authors:  Johan W Jonker; Jae Myoung Suh; Annette R Atkins; Maryam Ahmadian; Pingping Li; Jamie Whyte; Mingxiao He; Henry Juguilon; Yun-Qiang Yin; Colin T Phillips; Ruth T Yu; Jerrold M Olefsky; Robert R Henry; Michael Downes; Ronald M Evans
Journal:  Nature       Date:  2012-05-17       Impact factor: 49.962

10.  FGF21 regulates metabolism and circadian behavior by acting on the nervous system.

Authors:  Angie L Bookout; Marleen H M de Groot; Bryn M Owen; Syann Lee; Laurent Gautron; Heather L Lawrence; Xunshan Ding; Joel K Elmquist; Joseph S Takahashi; David J Mangelsdorf; Steven A Kliewer
Journal:  Nat Med       Date:  2013-08-11       Impact factor: 53.440
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  38 in total

1.  FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice.

Authors:  Qingzhi Wang; Jing Yuan; Zhanyang Yu; Li Lin; Yinghua Jiang; Zeyuan Cao; Pengwei Zhuang; Michael J Whalen; Bo Song; Xiao-Jie Wang; Xiaokun Li; Eng H Lo; Yuming Xu; Xiaoying Wang
Journal:  Mol Neurobiol       Date:  2017-07-15       Impact factor: 5.590

2.  Sex-specific brain erythropoietin regulation of mouse metabolism and hypothalamic inflammation.

Authors:  Soumyadeep Dey; Zhenzhong Cui; Oksana Gavrilova; Xiaojie Zhang; Max Gassmann; Constance T Noguchi
Journal:  JCI Insight       Date:  2020-03-12

Review 3.  FGF21 and metabolic disease in 2016: A new frontier in FGF21 biology.

Authors:  Matthew J Potthoff
Journal:  Nat Rev Endocrinol       Date:  2016-12-16       Impact factor: 43.330

Review 4.  Liver function and dysfunction - a unique window into the physiological reach of ER stress and the unfolded protein response.

Authors:  D Thomas Rutkowski
Journal:  FEBS J       Date:  2018-02-07       Impact factor: 5.542

Review 5.  Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis.

Authors:  Justin D Schumacher; Grace L Guo
Journal:  Handb Exp Pharmacol       Date:  2019

6.  NRG1-Fc improves metabolic health via dual hepatic and central action.

Authors:  Peng Zhang; Henry Kuang; Yanlin He; Sharon O Idiga; Siming Li; Zhimin Chen; Zhao Yang; Xing Cai; Kezhong Zhang; Matthew J Potthoff; Yong Xu; Jiandie D Lin
Journal:  JCI Insight       Date:  2018-03-08

7.  FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver.

Authors:  Stephanie von Holstein-Rathlou; Lucas D BonDurant; Lila Peltekian; Meghan C Naber; Terry C Yin; Kristin E Claflin; Adriana Ibarra Urizar; Andreas N Madsen; Cecilia Ratner; Birgitte Holst; Kristian Karstoft; Aurelie Vandenbeuch; Catherine B Anderson; Martin D Cassell; Anthony P Thompson; Thomas P Solomon; Kamal Rahmouni; Sue C Kinnamon; Andrew A Pieper; Matthew P Gillum; Matthew J Potthoff
Journal:  Cell Metab       Date:  2015-12-24       Impact factor: 27.287

8.  Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice.

Authors:  Curtis C Hughey; Freyja D James; Deanna P Bracy; E Patrick Donahue; Jamey D Young; Benoit Viollet; Marc Foretz; David H Wasserman
Journal:  J Biol Chem       Date:  2017-10-16       Impact factor: 5.157

Review 9.  Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis.

Authors:  Lucas D BonDurant; Matthew J Potthoff
Journal:  Annu Rev Nutr       Date:  2018-05-04       Impact factor: 11.848

Review 10.  FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process.

Authors:  Antero Salminen; Anu Kauppinen; Kai Kaarniranta
Journal:  J Mol Med (Berl)       Date:  2016-09-27       Impact factor: 4.599
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